Parkinson's disease (PD) is a common neurodegenerative disorder that involves the selective degeneration of midbrain dopaminergic neurons. Recently DJ-1 mutations have been linked to autosomal-recessive early-onset Parkinsonism in two European families. By using gel filtration assays under physiological conditions we demonstrate that DJ-1 protein forms a dimeric structure. Conversely, the DJ-1L...

Let G = (V,E), V {1,2,...,n}, be a simple connected graph of order n, size m with vertex degree sequence d1 ? d2 ... dn > 0, di d(vi). The geometric-arithmetic topological index is defined as GA(G) i~j 2? didj/di+dj, whereas the coindex GA?(G) i~/j 2 didj/di+dj . New lower bounds for and in terms some parameters other invariants are obtained.

Nuclear reprogramming of differentiated cells can be induced by oocyte factors. Despite numerous attempts, these factors and mechanisms responsible for successful reprogramming remain elusive. Here, we identify one such factor, necessary for the development of nuclear transfer embryos, using porcine oocyte extracts in which some reprogramming events are recapitulated. After incubating somatic n...

Patients with diabetes are more vulnerable to renal ischemia/reperfusion (I/R) injury, which is implicated in hyperglycemia-induced oxidative stress. We previously reported that the hyperglycemia-induced inhibition of DJ-1, a novel oncogene that exhibits potent antioxidant activity, is implicated in the severity of myocardial I/R injury. In the present study, we aimed to explore the role of DJ-...

At the end of every year the Value Line (VL) Corporation publishes its forecasts of the Dow Jones Index and its probable ranges for the coming three years using a three explanatory variable multiple regression model that we call the Value Line Dow Jones (VL-DJ) model. The model is a static time series model. Therefore, forecasts of the Dow Jones Index rely on forecasts of the independent variab...

Parkinson's disease (PD) is a major neurodegenerative condition with several rare Mendelian forms. Oxidative stress and mitochondrial function have been implicated in the pathogenesis of PD but the molecular mechanisms involved in the degeneration of neurons remain unclear. DJ-1 mutations are one cause of recessive parkinsonism, but this gene is also reported to be involved in cancer by promoti...

Recently, the media monitoring industry shows increased interest in applying automated audio identification systems for revenue distribution of DJ performances played in discotheques. DJ mixes incorporate a wide variety of signal modifications, e.g. pitch shifting, tempo modifications, cross-fading and beat-matching. These signal modifications are expected to be more severe than what is usually...

Parkinson's disease (PD) is the second most common neurodegenerative disorder. We have found that salidroside (Sal) exhibited neuroprotective effects against MPP+ toxicity. However, the molecular mechanism is not fully understood. In this study, we found that Sal significantly prevented MPP+-induced decrease of mRNA and protein expression of Nrf2, GCLc, SOD1, and SOD2 in SH-SY5Y cells. Moreover...

PEDRO K. BEREDJIKLIAN Presentations • Rosental TD, Beredjiklian PK, Weiland AJ: Intraand interobserver reliability of sensibility testing in normal subjects. American Society for Surgery of the Hand 54 Annual Meeting, Boston, MA, 1999. • Bozentka DJ, Hunt TR, Beredjiklian PK: Acute calcific periarthritis of the wrist. American Association for Hand Surgery 30 Annual Meeting, Miami, FL, 2000. • B...