BACKGROUND In many developing countries, cereal and legume-based diets contain low amounts of bioavailable iron, which may increase the risk of iron deficiency. OBJECTIVE The objective was to measure change in iron status in Moroccan children who consumed their habitual diet containing low amounts of bioavailable iron. DESIGN The design was a prospective, longitudinal, free-living cohort st...

Intravenous iron is widely used to maintain adequate iron stores and prevent iron deficiency anemia in patients with chronic kidney disease, yet concerns remain about its long-term safety with respect to oxidative stress, kidney injury, and accelerated atherosclerosis, which are the subjects of this review. Three parenteral iron formulations are available for use in the United States: Iron dext...

in the present study, effects of iron excess treatments (0, 250, 500 mg l-1) were evaluated in four rice varieties including shafagh, khazar, hashemi and sadri in pot condition. afterward, effects of iron excess (10 and 250 mg l-1) were further investigated in the most resistant variety (shafagh) in sand culture with yoshida nutrient solution. this experiment was arranged as factorial in rcbd w...

conclusions further studies on the role of hepcidin in pathogenesis of chc are needed to assess the potency of its use in antiviral treatment. results patients with chc had lower hepcidin mrna expression and more frequently iron deposits in hepatocytes than subjects with chb did. in chc group, hepcidin mrna expression was positively correlated with alanine aminotransferase activity and serum ir...

background: the prevalence of obesity is increasing and many countries are struggling with its high rate and serious complications. as a result of distinct diet in obese children, they may be susceptible to nutritional deficiencies in particular, iron deficiency. this study aimed to examine the relationship between obesity and iron indices. methods: in this cross-sectional study, 206 elementary...

UNLABELLED BACKGROUND Patients with inflammatory bowel disease (IBD) frequently appear iron deplete but whether this is a reflection of dietary iron intakes is not known. METHODS Dietary data were collected from 29 patients with inactive or mildly-active IBD and 28 healthy controls using a validated food frequency questionnaire that measured intakes of iron and its absorption modifiers. No...

Genetic and dietary forms of iron overload have distinctive clinical and pathophysiological features. HFE-associated hereditary hemochromatosis is characterized by overwhelming intestinal iron absorption, parenchymal iron deposition, and macrophage iron depletion. In contrast, excessive dietary iron intake results in iron deposition in macrophages. However, the functional consequences of geneti...

Background: A large oral dose of iron will reduce the absorption of a subsequent smaller dose of iron in a phenomenon known as mucosal block. Molecular analysis of this process may provide insights into the regulation of intestinal iron absorption. Aims: To determine the effect of an oral bolus of iron on duodenal expression of molecules associated with intestinal iron transport in rats and to ...

the characteristics of manganese and iron binding to human apotransferrin (apo-tf) have been investigated and compared in this study. both metal ions were taken up by human apo-tf and formed complexes, with the maximum absorbances observed at 410 and 340 nm for manganese-transferrin (mn-tf) and 465 nm for iron-transferrin (fe-tf). addition of manganese (1.5 µg/ml) to the reaction mixture contai...