Concern exists regarding adverse metabolic effects of antihypertensive agents. In the United States, diuretics are recommended first-line but additional agents, usually angiotensin-converting enzyme (ACE) inhibitors, are often required to meet blood pressure targets. We have previously shown that the combination of low-dose diuretic with an ACE inhibitor has detrimental effects on insulin actio...

Polyscias fruticosa (L.) Harm (Family: Araliaceae) is possibly native to Malaysia, but now widely cultivated in tropical areas and as a greenhouse plant. In Fiji, the root is used as a diuretic. The juice from the bark is taken for thrush and an ulcerated tongue or throat. A poultice made from the bark is used on syphilitic sores. The present study was undertaken to investigate diuretic effect ...

Alismatis rhizoma (AR), the dried rhizoma of Alisma orientale Juzepzuk (Alismataceae), is a traditional Chinese medicine. AR is an important part of many prescriptions and is commonly used as a diuretic agent in Asia. This study aimed to evaluate the diuretic effects of total triterpene extract (TTE) and triterpene component compatibility (TCC, the mixture of alisol B 23-acetate, alisol B, alis...

AIM To assess the effects of a combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients. METHODS A two-center, randomized, open-label, prospective study was conducted. Japanese patients who met the criteria were randomized to trial group and the combination diuretic group (received 7.5 mg of tolvaptan) or the conventional diuretic group (received 40 mg of furosem...

PRIOR TO the advent of potent oral diuretics, pareliteral mercurial drugs were the mainstays of diuretic therapy. In the search for orally effective diuretic agents, several events stand out. In 1949, Schwartz1 reported the diuretic effect of sulfanilamide in patients with congestive heart failure. In 1953, acetazolamide, a sulfonamide derivative and a potent carbonic anhydrase inhibitor, becam...

The present study was undertaken to investigate the diuretic effect of ethanolic seed extracts of Macrotyloma uniflorum and Cucumis melo in Albino rats. Ethanolic extracts of the seeds were administered to experimental rats orally at doses of 200mg/kg and 400mg/kg each p.o. Furosemide (5mg/kg) was used as a standard. The diuretic effects of the extracts were evaluated by measuring the Urine vol...

Peripheral oedema is a commonly encountered clinical problem. Although it has many causes, its pathophysiology ultimately involves two processes: altered capillary haemodynamics and renal salt and water retention. A minority of cases are resistant to diuretic treatment; causes of such resistance include excessive sodium intake, poor diuretic drug absorption, reduced secretion of free diuretic i...

Andrographis echioides Andrographis echioides is used in the traditional medicine as diuretic. In the present study, the diuretic activity of Petroleum ether, Chloroform extract of Andrographis echioides was studied and the activity was compared with furosimide as standard. The Chloroform extract exhibited significant diuretic activity as evidenced by increased total urine volume and the urine ...

ipomoea reniformis roxb. (convolvulaceae) is a small, weedy herb used for the management of cardiac problems in traditional systems of medicine in india and pakistan. objective of the present study is to investigate the hypotensive, diuretic and angiotensin converting enzyme (ace) inhibitory activities of the aqueous-methanol (30:70) crude extract of the dried aerial parts of i. reniformis (ir....