Abbreviations: 1,5-dihydroxyisoquinoline, (DHIQ); 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone, (DPQ); apoptosisinducing factor, (AIF); apoptosis-signal regulating kinase, (ASK); butylated hydroxyanisole, (BHA); embryonic stem, (ES); interleukin1, (IL-1); Drosophila JNK, (DJNK); c-Jun N-terminal kinase, (JNK); lipopolysaccharide, (LPS); mitochondrial membrane permeabilization, (...

A cadmium tetrahydroisoquinoline dithiocarbamate (DTC) complex has been used as single-source precursor for the synthesis of highly faceted hexadecylamine (HDA) capped CdS nanoparticles. Hexagonal and close to cubic shaped particles with distinct lattice fringes are visible in the high resolution transmission electron microscopy images. Crystalline particles in the shape of a hexagon are clearl...

The detoxification of the phytoalexin brassinin to indole-3-carboxaldehyde and S-methyl dithiocarbamate is catalyzed by brassinin oxidase (BOLm), an inducible fungal enzyme produced by the plant pathogen Leptosphaeria maculans. Twenty-six substituted quinolines and isoquinolines are synthesized and evaluated for antifungal activity against L. maculans and inhibition of BOLm. Eleven compounds th...

A series of novel 2-methyl-3-substituted quinazolin-4-(3H)-ones have been synthesized by treating (2-methyl-4-oxo-3H-quinazolin-3-yl)dithiocarbamic acid methyl ester with different amines, the starting material dithiocarbamate was synthesized from anthranilic acid. The compounds synthesized were investigated for analgesic, anti-inflammatory and antibacterial activities. All the test compounds e...

Separation of a number of transition metal complexes with bis(2-hydroxyethyl)dithiocarbamate (HEDTC) by micellar electrokinetic capillary chromatography (MEKC) with direct photometric detection was investigated. Pre-capillary complexation was shown to be superior to on-capillary complexation in terms of the number of metals ions which could be detected and their peak shapes, enabling analysis o...

Sodium metam (NaM), a dithiocarbamate, is a general agricultural biocide applied prior to planting for the elimination of nematodes, soil pathogens, and weeds. There is a remarkable paucity of information about the mechanism of action and the risk that dithiocarbamates may pose to developing vertebrates. We have characterized NaM toxicity during early life stage exposure in zebrafish. Zebrafish...

In this research, 15 novel derivatives of the thiazolactone skeleton were synthesized using Erlenmeyer–Plöchl reaction procedure. Glycine, alanine and leucine amino acids used to make dithiocarbamate precursor by reacting with carbon disulfide benzyl chloride. Obtained underwent formation in presence acetic anhydride then condensed arylglyoxals as condensing carbonyl group source. Products char...