The trial was both an early demonstration of the potential of disulfiram in the right circumstances and of sanctions contingent on (effectively) abstinence. This entry is our analysis of a study considered particularly relevant to improving outcomes from drug or alcohol interventions in the UK. The original study was not published by Findings; click Title to order a copy. Free reprints may be a...

We developed a competition-based screening strategy to identify compounds that invert the selective advantage of antibiotic resistance. Using our assay, we screened over 19,000 compounds for the ability to select against the TetA tetracycline-resistance efflux pump in Escherichia coli and identified two hits, β-thujaplicin and disulfiram. Treating a tetracycline-resistant population with β-thuj...

1. McCullough PA. Contrast‐induced acute kidney injury. J Am Coll Cardiol 2008;51:1419‐28. 2. Mercer JB, Ring EF. Fever screening and infrared thermal imaging: Concerns and guidelines. Thermology Int 2009;19:67‐99. 3. Urakov AL, Kasatkin AA, Urakova NA, Ammer K. Infrared thermographic investigation of fingers and palms during and after application of cuff occlusion test in patients with hemorrh...

The anticancer activity of disulfiram (DS) is copper(ii) (Cu)-dependent. This study investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our study indicates that DS/Cu targets cancer cells by the combination of two types of actions: (1) instant killing executed by DS/Cu reaction generated reactive oxygen species; (2) delayed cytotoxicity in...

The efficacy of medications for alcohol dependence remains modest, and there are no strong clinical predictors of treatment response. Approved medications include acamprosate (an N-methyl-d-aspartate receptor (NMDA) modulator), disulfiram (an acetaldehyde dehydrogenase inhibitor) and naltrexone (an opioid antagonist) while nalmefene (an opioid antagonist) is currently under review for approval ...

Bovine lens cytoplasmic aldehyde dehydrogenase exhibits Michaelis-Menten kinetics with acetaldehyde, glyceraldehyde 3-phosphate, p-nitrobenzaldehyde, propionaldehyde, glycolaldehyde, glyceraldehyde, phenylacetylaldehyde and succinic semialdehyde as substrates. The enzyme was also active with malondialdehyde, and exhibited an esterase activity. Steady-state kinetic analyses show that the enzyme ...

GENERIC NAME PAGE Alfentanil 408 Amobarbital 411 Amphetamine 410 Buprenorphine 408 Butorphanol 408 Caffeine 410 Chlordiazepoxide 411 Cocaine 410 Diazepam 411 Disulfiram 415 Ethanol 412 Fentanyl 408 Flurazepam 411 Heroin 409 Lorazepam 411 LSD 417 GENERIC NAME PAGE Marijuana 416 MDA 418 MDMA 418 Mescaline 417 Methadone 408 Methamphetamine 410 Methylphenidate 410 Midazolam 411 Morphine 409 Nicotin...