Doxazosin mesylate (DXM) sustained release pellets were prepared by an extrusion-spheronization and fluid-bed coating technique. The core pellets containing DXM were prepared by extrusion-spheronization technique, and coated by a fluid-bed coater to control the release of DXM. The factors affecting to properties of pellets, such as diluent content, type and coating level of coating agents and p...

A dissolution test for in vitro evaluation of tablet dosage forms containing 10 mg of rupatadine was developed and validated by RP-LC. A discriminatory dissolution method was established using apparatus paddle at a stirring rate of 50 rpm with 900 mL of deaerated 0.01 M hydrochloric acid. The proposed method was validated yielding acceptable results for the parameters evaluated, and was applied...

Often the quality of drug products is evaluated based on chemical tests, commonly described in different pharmacopeias such as the USP. These tests includes: assay (potency), uniformity of dosage form and dissolution test. Presently, these tests are conducted separately with three procedures. Furthermore, dissolution tests are also conducted using multiple product-specific procedures. This make...

“Guaraná” (Paullinia cupana) is used as a physical activity enhancer and stimulator due to its methylxanthines and condensed tannins. The aim of this work was to evaluate the dissolution behavior of five herbal medicines in the form of capsules and tablets containing guaraná. Assay and dissolution methods were validated and results obtained allowed simultaneous marker quantification with precis...

The objective of the current study was to determine tablet content and perform dissolution test of expired tablets and tablets which expiry date has not exceeded. The analyzed tablets contained metoprolol tartrate (50 mg) and propranolol hydrochloride (10 mg), respectively. Content determination was performed using spectrophotometric method with UV detection; the percent of dissolved substance ...

Environmental reconstructions are limited by the quality of the original data from which they are derived. In situations where microfossils are poorly preserved problems may arise, both through taxonomic uncertainty and more subtly from the alteration of the death assemblage as a result of the differential robustness of species. Diatom dissolution tends to be a particular problem in saline lake...

Dissolution studies have become matter of great significance because, in most cases, drug dissolution is the rate-limiting step in the absorption process. As occurs with solid oral dosage forms, heterogeneous disperse systems (suspensions) could also have some problems with their in vitro dissolution. The dissolution behavior of four different brands of cefadroxil extemporaneous suspensions ava...

Literature data are reviewed on the properties of ibuprofen related to the biopharmaceutics classification system (BCS). Ibuprofen was assessed to be a BCS class II drug. Differences in composition and/or manufacturing procedures were reported to have an effect on the rate, but not the extent of absorption; such differences are likely to be detectable by comparative in vitro dissolution tests. ...

Theoretical calculations have shown that acidic candies may be potentially erosive upon consumption. However, little is known about the protective effect of adding calcium to potentially erosive candies and about the protective effects of saliva that cannot be fully accounted for by theoretical calculations. Therefore, the aims of this study were to (1) determine the erosive potential of acidic...

Introduction In vitro dissolution testing is a critical component in the assessment of quality of a pharmaceutical product and for the validation of the development and manufacturing process of a product (1). Dissolution testing is also used to assess the rate at which a drug is released from a dosage form,as it provides a manufacturer with a rational basis on which to predict in vivo behaviour...