The hydrometallurgical method for processing chalcopyrite ore has gained enormous attention due to the environmental problems emanated by conventional pyrometallurgical route. Here, hydrometallurgy is considered an alternative that may be more of low-cost and environmentally friendly. Thus, alkaline leaching been effective, efficient, acceptable leachant dissolution. dissolution behaviour coppe...

Drug product performance testing is an important part of quality-by-design approaches, but this process often lacks the underlying mechanistic understanding of the complex interactions between the disintegration and dissolution processes involved. Whereas a recent draft guideline by the US Food and Drug Administration (FDA) has allowed the replacement of dissolution testing with disintegration ...

It has been considered that the corrosion of passive metals and alloys is not caused by the active metal-dissolution but the dissolution of a nonporous passive oxide film in aqueous solution. The corrosion current density of iron(1)(2), chromium(3) and their alloys(4) is independent of the potential in all the range of passivity, although depending upon the pH of solution. Vetter(1) explained s...

The objectives of this study were to prepare bosentan hydrate (BST) microparticles as dry powder inhalations (DPIs) via spray drying and jet milling under various parameters, to comprehensively characterize the physicochemical properties of the BST hydrate microparticles, and to evaluate the aerosol dispersion performance and dissolution behavior as DPIs. The BST microparticles were successfull...

Cellulose is present in biomass as crystalline microfibrils held together by a complex network of intermolecular interactions making it difficult to initiate its hydrolysis and conversion to fuels. While cellulose is insoluble in water and most organic solvents, complete dissolution of cellulose can be achieved in certain classes of ionic liquids (ILs). The present study was undertaken to analy...

a simple and sensitive chemiluminescence-based method was established for the determination of rabeprazole.the proposed method was based on the enhancing effect of rabeprazole on ce(iv)-na2so3 -tb(iii) chemiluminescence reaction. a possible mechanism was discussed for chemiluminescence system by studying uv-vis, fluorescence and chemiluminescence spectra. the effects of various chemical paramet...

Nebivolol hydrochloride is a poorly water soluble drug falls under class II biopharmaceutical classification system, which is β1 receptor antagonist that leads to vasodilatation, decreased peripheral vascular resistance, lowers blood pressure and heart rate. The rate of its oral absorption is often controlled by dissolution rate in the gastro intestinal tract. The aim of the present investigati...

A simple and sensitive chemiluminescence-based method was established for the determination of rabeprazole.The proposed method was based on the enhancing effect of rabeprazole on Ce(IV)-Na2SO3 -Tb(III) chemiluminescence reaction. A possible mechanism was discussed for chemiluminescence system by studying UV-Vis, fluorescence and chemiluminescence spectra. The effects of va...

Curcumin is a phytoconstituent with wide range of biological activity. It is poorly soluble in water. In the present study a new dissolution medium was developed, as there is no validated dissolution method available in the literature. The composition of the dissolution medium was selected on the basis of solubility data at 37 degrees . Solubility data revealed that addition of surfactant may b...

The aims of the study were to observe the dissolution profile of four types of selected fruit powder fast dissolve tablet and apply different dissolution profile comparison methods, in order to select most applicable method. Spray dried powder of pitaya, pineapple, guava and mango were used as raw material. Each type of fruit powder tablet has identical dissolution profile. Dissolution profiles...