Type 2 diabetes mellitus (T2DM) is a complex metabolic disease threatening human health. We investigated the effects of Tegillarca granosa polysaccharide (TGP) and determined its potential mechanisms in mouse model T2DM established through high-fat diet streptozotocin. TGP (5.1×103 Da) was composed mannose, glucosamine, rhamnose, glucuronic acid, galactosamine, glucose, galact...

Lespedeza cuneata, belonging to Fabaceae, is well-known as Chinese bushclover, and it has been used in traditional folk medicines for the treatment of disorders, such diabetes, hematuria, insomnia. As part continuing research projects discover interesting natural compounds with biological activities from Korean medicinal plants, phytochemical investigation L. cuneata resulted isolation five che...

Objective: Type2 diabetes (T2DM) as a metabolic disease is associated with absolute or relative insulin deficiency, increased blood glucose and carbohydrate metabolism disorders which is considered as risk factors of other diseases such as cardiovascular diseases. In the present study, the effect of eight weeks of high intensity interval training (HIIT) on lipid profile (TG, LDL and HDL), gluco...

Nuclear receptors form a superfamily of proteins that function as ligand-activated transcription factors. One of the authors has pointed out that pathways and networks formed by the nuclear receptors, their ligands, target genes of the nuclear receptors, and their product proteins plays important roles in endocrine regulation, drug and xenobiotic metabolism, and metabolic disorders such as Synd...

Low-molecular weight organic chromium complexes are thought to play a key role in carbohydrate and lipid metabolism and therefore have been gaining popularity as nutritional supplement for patients with diabetes and concomitant lipid disorders. The aim of the present study was to evaluate the effects of a novel synthetic chromium (d-phenylalanine)(3) complex on insulin-sensitivity, plasma lipid...

Metabolic related diseases, such as type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD), are widespread threats which bring about a significant burden of deaths worldwide, mainly due to cardiovascular events and cancer. The pathogenesis of these diseases is extremely complex, multifactorial, and only partially understood. As the main metabolic organ, the liver is c...

The Liver and Hepatobiliary System Metabolic Functions of the Liver Carbohydrate, Protein, and Lipid Metabolism Drug and Hormone Metabolism Bile Production and Cholestasis Cholestasis Bilirubin Elimination Tests of Hepatobiliary Function Disorders of the Liver Hepatitis Acute Viral Hepatitis Chronic Hepatitis Intrahepatic Biliary Disorders Primary Biliary Cirrhosis Primary Sclerosing Cholangiti...

White blood cell (WBC) count has been associated with diabetic risk, but whether the correlation is independent of other risk factors has hardly been studied. Moreover, very few such studies with large sample sizes have been conducted in Chinese. Therefore, we investigated the relationship between WBC count and glucose metabolism in China. We also examined the relevant variables of WBC count. A...

Introduction: It has been shown that olive leaf extract exerts (OLE) a positive effect on lipid and blood glucose levels; however, the mechanism remains poorly understood. This study aimed to examine behind this by evaluating proteins related metabolism, including transporter 4 (Glut4), Akt Substrate of 160 kDa (AS160), adenosine monophosphate-activated protein kinase (AMPK α2). Methods: Eighty...