Over the past decade, a body of evidence has accumulated demonstrating that calcific aortic valve disease (CAVD) is prevalent in older adults and that the presence of calcific valve disease is associated with adverse clinical outcomes, even in the absence of left ventricular (LV) outflow tract obstruction. Stritzke et al. report for the KORA/MONICA study that degenerative (or calcific) aortic v...

BACKGROUND Chronic obstructive pulmonary disease (COPD) mainly affects middle-age and elderly adults. It is unclear if the presence of muscle wasting and fat accumulation in patients with COPD is age or disease-related. This study investigated the effect of age and COPD disease severity on body composition with the aim of identifying a biomarker(s) for COPD. METHODS Healthy subjects and patie...

Alzheimer disease is characterized by the accumulation of abnormally folded protein fragments, i.e., amyloid beta peptide (Abeta) and tau that precipitate in amyloid plaques and neuronal tangles, respectively. In this review we discuss the complicated proteolytic pathways that are responsible for the generation and clearance of these fragments, and how disturbances in these pathways interact an...

background : pancreas as the insulin-producing gland is subjected to destruction and change in the diabetes-producing process. realtime sonography can assess the gland in 95% of cases and its accuracy in diagnosis of pancreatic disease matches that of ct-scan. the purpose of this study was to evaluate pancreatic diameter and echogenicity by sonography and to examine the correlation of these two...

langerhans cell histiocytosis is a relatively rare unique disease process characterized by an abnormal proliferation of immature dendritic cells usually affecting children and young adults. jaws are involved in less than 10% of children with the disease while mandibular involvement in young children is uncommon and bilateral affection is very rare. the purpose of this report is to describe a un...