Since 1975, none of our patients with Perthes' disease have received any active treatment, except for managing severe pain. We have studied the functional and radiological results in order to evaluate the consequences of this approach and to demonstrate the natural history of the disease. We have followed up all patients over the age of 19 years; out of 20 only 6 were free of pain and only 2 re...

CASS includes a multicenter patient registry and a randomized controlled clinical trial. It is designed to assess the effect of coronary artery bypass surgery on mortality and selected nonfatal end points. From August 1975 to May 1979, 780 patients with stable ischemic heart disease were randomly assigned to receive surgical (n = 390) or nonsurgical (n = 390) treatment and were followed through...

The natural history of aortoarteritis was studied in 88 patients (54 women and 34 men). The average age was 24.0 +/- 8.8 years at onset of symptoms and 28.3 +/- 9.9 years at diagnosis. The follow-up period was 83.6 +/- 74.4 months from onset and 33.2 +/- 37.0 months from diagnosis. Ten patients (11.4%) died during follow-up (0.016 deaths/patient year), and 22 patients (25%) suffered major nonfa...

The prolate ellipsoid geometry of the left ventricle with normally related great arteries minimizes wall tension and functionally commits the ventricular septum to the systemic ventricle. Ageand pressure-dependent changes in angiographically determined left ventricular volume and mass measurements have been reported in patients with d-transposition of the great arteries and intact interventricu...

The New Zealand essays are less focused and assured than those in the MacLeod-Denoon collection. They are centred on the development of the health professions, hospitals, public health policies and womens' health. There is, unfortunately, no introductory overview of New Zealand as "a healthy country" which might set the various contributions in context. The strongest papers are those by Derek D...

The functional and prognostic significance of exercise-induced ST elevation (by computer averaging) in ambulatory patients with coronary heart disease was recently reported for 181 patients in the Seattle Heart Watch (SHW). To further evaluate this, 3050 approximately similar patients enrolled in CASS were analyzed with respect to initial findings, survival, and incidence of secondary coronary ...

The incidence of previous coronary artery bypass surgery (CABS) in patients with acute myocardial infarction admitted to our hospital has risen from 2.3% to 11.2% in 6 years. We compared infarct size and the angiographically determined cause of infarction in 52 control patients and in 52 consecutive patients with acute myocardial infarction at least 2 months after they had undergone CABS. Basel...

ATHEROSCLEROSIS is a progressive disease which is usually silent clinically until late in its course. The reasons for the clinical silence are apparent upon study of the pathology of the disease. Early atherosclerosis is an inflammatory disease which destroys the normal anatomy of the arterial wall. The destruction of the elastin in the wall causes arterial dilation. Only late in its course doe...

It is puzzling why countries do not all implement stringent behavioral control measures to prevent the spread of COVID-19 even though preventive behaviors have been proven be only effective means stop pandemic. We provide a novel evolutionary life history explanation whereby pathogenic and parasitic prevalence represents intrinsic rather than extrinsic mortality risk that drives slower strategi...