نتایج جستجو برای: discontinuation reason
تعداد نتایج: 118143 فیلتر نتایج به سال:
OBJECTIVE Ovarian cancer is the most lethal cancer involving the female pelvic reproductive system. Its incidence increases with age and with an aging population, its prevalence should also increase. The goal of our retrospective study is to report our experience in treating women over 65 years of age, with a diagnosis of primary ovarian cancer, using standard intravenous chemotherapy. METHOD...
Improvement in perinatal care have resulted in significantly increased survival of premature infants. Discontinuation of correct intrauterine lung development and a necessity of oxygen-therapy and/or mechanical ventilation become a reason of bronchopulmonary dysplasia (BPD). In the first period of life the main complaint of these patients is oxygen dependence. Moreover the risk of serious infec...
The aim of this study was to determine risk factors for adverse events (AE)-related treatment discontinuation and severe anemia among patients with chronic hepatitis C virus (HCV) genotype 1 infection, treated with first-generation protease inhibitor (PI)-based therapy. We included all patients who initiated treatment with PI-based therapy at a Brazilian university hospital between November 201...
BACKGROUND Current therapy for chronic hepatitis C virus (HCV) infection is effective in less than 50% of patients infected with HCV genotype 1. Telaprevir, a protease inhibitor specific to the HCV nonstructural 3/4A serine protease, rapidly reduced HCV RNA levels in early studies. METHODS We randomly assigned patients infected with HCV genotype 1 to one of three telaprevir groups or to the c...
OBJECTIVE To assess the safety, tolerability, and pharmacokinetic and pharmacodynamic effects of the -secretase inhibitor avagacestat in patients with mild to moderate Alzheimer disease (AD). DESIGN Randomized, double-blind, placebo-controlled,24-week phase 2 study. SETTING Global, multicenter trial. PATIENTS A total of 209 outpatients with mild to moderate AD were randomized into the dou...
Elevation of serum amylase level is usually associated with pancreatitis, but 2% of cases are associated with medication. Only 1 case of pancreatitis caused by sertraline has been reported. Although it has been reported that selective serotonin reuptake inhibitors may rarely cause pancreatitis, Elevated serum amylase levels associated with sertraline use in cases without pancreatitis has not be...
OBJECTIVES To evaluate the frequency of and predictive factors for nevirapine-based highly active antiretroviral therapy (HAART) discontinuation. METHODS All patients receiving nevirapine as a component of HAART at our centre were retrospectively evaluated for efficacy and tolerability. Logistic regression was used to evaluate the influence of baseline characteristics on the outcome and Kapla...
OBJECTIVE The aim of the present study was to investigate differences in discontinuation time among antidepressants and total antidepressant discontinuation rate of patients with depression over a 6 month period in a naturalistic treatment setting. METHODS We reviewed the medical records of 900 patients with major depressive disorder who were initially prescribed only one kind of antidepressa...
PURPOSE Proton pump inhibitors (PPIs) are considered to be overprescribed. Consensus on how to attempt discontinuation is, however, lacking. We therefore conducted a systematic review of clinical studies on discontinuation of PPIs. METHODS Systematic review based on clinical studies investigating discontinuation strategies and discontinuation rates for users of antisecretory medication judged...
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