Background Maternal vaccination against group B Streptococcus (GBS) might provide protection against invasive GBS disease in infants. We investigated the kinetics of transplacentally transferred GBS serotype-specific capsular antibodies in the infants and their immune response to diphtheria toxoid and pneumococcal vaccination. Methods This phase 1b/2, observer-blind, single-center study (NCT0...

other parts of the world. Certain workers have recorded that this antitoxic immunity to diphtheria was more marked amongst the local ^habitants than in European children living in same place. That this difference in anti?xic immunity is not a result of any racial Peculiarities but the result of environmental c?nditions has been well shown in a critical i^rvey of the literature bv Dudley (1929) ...

DIPHTHERIA immunisation has been criticised recently on two counts. First, as one type of trauma to muscle which may influence the site of paralysis in persons incubating poliomyelitis; and second, on its failure to restrict epidemic spread of the gravis strain of diphtheria bacillus. Evidence of an association between the site of a previous inoculation and the site of paralysis in poliomyeliti...

AIMS The study was conducted to evaluate the possibility of selecting convalescent diphtheria patients to serve in emergency situations as donors for the production of anti-diphtheria immunoglobulin. To select suitable donors, the criterion of an antitoxin titer >/=3.0 IU/ml was used. In addition, the effects of treatment and the effect of immunization with diphtheria toxoid on the level of ant...

INTRODUCTION Subcutaneous (SQ) vaccination has emerged as standard of care in children with severe bleeding disorders to reduce unnecessary factor exposure and avoid provoking an intramuscular bleed, but little is known about comparative immunogenicity to intramuscular (IM) vaccination. AIM To confirm immunogenicity of Diphtheria Tetanus acellular Pertussis (DTaP) vaccines administered SQ to ...

Epidemic diphtheria reemerged in the republic of Georgia in 1993. From 1993 to 1997, 1405 cases were reported (28 in 1993, 312 in 1994, 429 in 1995, 348 in 1996, and 288 in 1997), with a cumulative incidence of 25.8/100,000 and a case fatality ratio of 9.5%. During 1993-1997, 53% of the diphtheria cases occurred among persons >/=15 years of age. Unvaccinated patients were more likely to have to...

From August till November 1998, the Paediatric and Anaesthetic Units of Hospital Kuala Terengganu managed three patients from Kuala Terengganu District who were ventilated for respiratory diphtheria. Their ages were 5, 4 and 7 years old and their immunisation for diphtheria were not complete. All three patients presented with respiratory distress and were ventilated for upper airway obstruction...

BACKGROUND It is known that antineoplastic treatment may induce secondary immunodeficiency, but studies after childhood sarcoma are rare. Since 1998, the Late Effects Surveillance System (LESS) of the German Society for Paediatric Oncology and Haematology (GPOH) prospectively registers late effects in soft tissue-, osteo- and Ewing's sarcoma patients treated within the therapy trials EICESS-92/...

Sir,?During the last five years I have come across only three genuine cases of diphtheria in Hyderabad. From one of these a pure culture of Diphtheria Bacillus was obtained, which in morphological and cultural characters and in pathogenic effects upon animals, proved to be identical with the specific bacillus discovered by Klebs and Loeffler. Hence it is clear from this, that diphtheria does oc...