BACKGROUND Active oxygen species can influence vascular tone and platelet activation through a variety of mechanisms. This study assessed the role of the superoxide anion, the hydroxyl radical, and hydrogen peroxide in vasoconstriction and mural thrombosis after coronary artery angioplasty in intact dogs. METHODS AND RESULTS Injury was induced by inflation of a balloon catheter 50 +/- 6% abov...

Dr. Takako Yokozawa, Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-01 (Japan) Dear Sir, Methylguanidine (MG) is a probable uremic toxin demonstrated to have a strong association with the induction of uremia. The idea that creatinine (Cr) is a precursor of MG is currently dominant. Giovannetti et al. [1],...

Myocardial ischemia and reperfusion can evoke excitation of cardiac vagal afferent nerve endings and activation of a cardiogenic depressor reflex (Bezold-Jarisch effect). We postulate that oxygen-derived free radicals, which are well known to be produced during prolonged ischemia and reperfusion, contribute to this excitation. Hydroxyl radicals derived from hydrogen peroxide (H202) activate abd...

BACKGROUND Cytotoxic products of neutrophils (polymorphonuclear leukocytes, PMNs) contribute to ischemia-reperfusion injury of several tissues. Hydrogen peroxide (H2O2), one of the cytotoxic products of PMNs, also promotes the adherence of PMNs to cultured vascular endothelial cells in vitro. The present study was undertaken to determine if H2O2 also augmented adhesion of PMNs to intact vessels...

INTRODUCTION Bacterial infection and bile flow retardation form a vicious cycle which promotes stone formation and recurrence, and it seems that mucin overexpression plays an important role in this process. However, the mechanism of increased mucus secretion in the biliary tract by bacterial infection and its treatment remain unclear. MATERIAL AND METHODS Human biliary epithelial cells were i...

•Unprecedented zirconocene catalysis in reductive ring opening of epoxides•Broad reactivity across diverse substrates, including natural products•Reverse regioselectivity compared with the well-established methods titanocene•Changing metal center metallocene alters reversibility Epoxides are key structural motifs commonly found products and medicinal agrochemical agents as well various intermed...

BODY: Abstract Body: The clinical success of cisplatin, and platinum based drugs,as anti-cancer agents constitutes the most important contribution to the use of metals in medicine.The major concerns associated with these anti-cancer metallodrugs, include problems with resistance, toxicity and other side effects.The main cellular target for platinum drugs is genomic DNA and the major antitumor a...