Mutations of the Shaker (Sh) locus of Drosophila reduce, eliminate, or otherwise alter a transient potassium current, IA, in muscle. Recent molecular studies indicate that the Sh locus produces several proteins by alternative splicing, but the relationships of the variety of Sh gene products to IA channels in the various excitable membranes still remain to be determined. In Drosophila, many enz...

Original full papers, not directly related to the subject of the thesis: NO-sensitive guanylyl cyclase beta 1 subunit is peripherally associated to chromosomes during mitosis. Abbreviations 2D-DIGE two-dimensional difference gel electrophoresis 2-DE two-dimensional electrophoresis AD Alzheimer's disease APP amyloid precursor protein Aβ amyloid-beta BSA bovine serum albumine CBB Coomassie brilli...

We analytically study second-harmonic (SH) generation from thin metallic films with subwavelength noncentrosymmetric patterns. Because the thickness of the film is much smaller than the SH wavelength, retardation effects are negligible. The far-field SH intensities are thus dominated by an effective electric dipole. It is further demonstrated that internal bulk SH polarization density is compar...

An interesting aminosilanetrithiol RSi(SH)3 (R = N(SiMe3)-2,6-iPr2C6H3) has been prepared by the reaction of lithium aminosilanetrithiolate {RSi[SLi(THF)]3}2 with MeCOOH. Theoretical calculations indicate that the LP(N) → σ*(Si-S) and LP(S) → σ*(Si-S) electron donations remarkably contribute to the stabilization of the Si(SH)3 part of the molecule. RSi(SH)3 is the first example of a stable mole...

The functionalization of elastomers by phosphonate groups remains relatively unexplored considering the great potential these polymers would represent for applications. In this paper, thiol-functional oligophosphonates were designed and coupled a thiol-ene reaction to styrene-butadiene rubber (SBR). We adopted RAFT methodology with dimethyl vinylphosphonate (DMVP) high-temperature thermolysable...

The production, optimisation and partial characterisation of xylanases from newly isolated wild strains of Coprinellus disseminatus was performed in solid-state fermentation. Strains SH-1 and SH-2 showed high xylanase (727.78 and 227.99 IU/mL) with very low CMCase (0.925 and 0.660 IU/mL) and laccase (0.640 and 0.742 U/mL) activities at incubation time seven days, 37 degrees C and initial pH 6.4...

The second harmonic (SH) generation from the highly epitaxial Al-doped ZnO film on sapphire was measured, using the femtosecond Ti:Sapphire laser at the near-resonant SH wavelength, in reflection geometry to avoid the sapphire's contribution in the conventional Maker fringes technique. By investigating SH intensities as a function of the azimuthal angle along the film's normal, we found that th...

This study examines the temporal evolution of the tropospheric circulation following large-amplitude variations in the strength of the Southern Hemisphere (SH) stratospheric polar vortex in data from 1979 to 2001 and following the SH sudden stratospheric warming of 2002. In both cases, anomalies in the strength of the SH stratospheric polar vortex precede similarly signed anomalies in the tropo...

This cross-sectional study examined differences in children's health behaviors during school term (ST) versus school holiday (SH: June-July) and how associations changed when weather characteristics were considered. Children aged 5-18 years (n = 406) from a subtropical climate reported behaviors over 20 months. Multivariable regression models controlling for age, sex, race and body mass index z...

Natural product curcumin (Cur) and H2S-releasing prodrug SH-aspirin (SH-ASA) are potential anticancer agents with diverse mechanisms, but their clinical application prospects are restricted by hydrophobicity and limited efficiency. In this work, we coencapsulated SH-ASA and Cur into methoxy poly(ethylene glycol)-poly (lactide-coglycolide) (mPEG-PLGA) nanoparticles through a modified oil-in-wate...