The Klebsiella pneumoniae mdcR gene, which encodes a LysR-type regulator, was overexpressed in Escherichia coli. Purified MdcR was found to bind specifically to the control region of either the malonate decarboxylase (mdc) genes or mdcR. We have also demonstrated that MdcR is an activator of the expression of the mdc genes, whereas it represses the transcription of the putative control region o...

The effects of halothane and diethyl ether on the regenerating liver following 70 per cent hepatectomy were studied in Fisher/344 (F) rats. Our aim was to discover whether halothane administered repeatedly and over prolonged periods could influence the liver regenerative process or hepatocyte function. We also wished to know if the effects of halothane differed from those of diethyl ether. We f...

In the title compound, C(7)H(11)NO(4), which is an example of a push-pull alkene, a network of N-H⋯O and C-H⋯O inter-actions helps to establish the crystal structure. The investigated crystal turned out to be a non-merohedral twin with a ratio of twin components of 0.442 (3):0.558 (3). Two pairs of independent mol-ecules (Z' = 4) are linked by inter-molecular N-H⋯O hydrogen bonds, forming indep...

In the title salt, C5H8N3 (+)·C3H3O4 (-), the 3,4-di-amino-pyridinium cation is almost planar, with an r.m.s. deviation of 0.02 Å. The conformation of the hydrogen malonate anion is stabilized by an intra-molecular O-H⋯O hydrogen bond, which generates an S(6) ring. In the crystal, N-H⋯O hydrogen bonds link cations and anions into layers parallel to the ab plane.

The melaminium (2,4,6-triamino-1,3,5-triazin-1-ium) cation in the title compound, C(3)H(7)N(6) (+)·C(3)H(3)O(4) (-), is essentially planar, with a r.m.s. deviation of the non-H atoms of 0.0085 Å. Extensive hydrogen bonding of the types N-H⋯N and N-H⋯O between cations and cations and between cations and hydrogen malonate (2-carb-oxy-ethano-ate) anions leads to the formation of supra-molecular la...

In this study, to examine the mechanism of diethyl phthalate toxicity to cells, the effects of diethyl phthalate on apoptosis in a PC12 cell system were investigated by assaying apoptotic factors such as caspase-3, Bax, cytochrome c and DNA damage. Diethyl phthalate was shown to enhance the apoptosis induced by serum deprivation according to the results of DNA electrophoresis and TUNEL signal a...

Diethyl sebacate is used in topical medicaments in United States and Japan. We described a case of allergic contact dermatitis from diethyl sebacate in a topical antimycotic medicament. Allergic reaction to diethyl sebacate is likely more common because our group has found three of eight sensitized cases. We believe that an investigation regarding the sensitized frequency to diethyl sebacate wo...

In the crystal structure of the title compound, [Zn(C(7)H(4)O(4)S)(C(10)H(8)N(2))(H(2)O)]·2H(2)O, the Zn(II) ion assumes a trigonal-bipyramidal coordination geometry completed by two N atoms from a 2,2'-bipyridine ligand, two O atoms from a 2-(3-thien-yl)malonate anion and a water mol-ecule. The S atom of the 2-(3-thien-yl)malonate ligand is disordered over two sites with an occupancy ratio of ...