نتایج جستجو برای: dicer

تعداد نتایج: 2241  

2016
Mohamad Reza Farzaneh Jahanbanoo Shahryari Akbar Safaei Behnaz Valibeigi Shahrbanou Karimi Davani Narjes Tabibi

Alterations in the expression of microRNAs (miRNAs) have been proposed to play a role in the pathogenesis of acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL). Dicer is one of the main regulators of miRNA biogenesis, and deregulation of its expression has been indicated as a possible cause of miRNA alterations observed in various cancers. Our aim was to analyze the expre...

Journal: :PLoS ONE 2008
Katsuhiko Hayashi Susana M. Chuva de Sousa Lopes Masahiro Kaneda Fuchou Tang Petra Hajkova Kaiqin Lao Donal O'Carroll Partha P. Das Alexander Tarakhovsky Eric A. Miska M. Azim Surani

BACKGROUND MicroRNAs (miRNAs) are critical regulators of transcriptional and post-transcriptional gene silencing, which are involved in multiple developmental processes in many organisms. Apart from miRNAs, mouse germ cells express another type of small RNA, piwi-interacting RNAs (piRNAs). Although it has been clear that piRNAs play a role in repression of retrotransposons during spermatogenesi...

2013
Yong-Feng Ren Guiling Li Yong-Feng Xue Xue-Jiao Zhang Yi-Jiang Song Lu Lv Jianmin Wu Yu-Xiao Fang Yu-Qun Wang Ke-Qing Shi Yong-ping Chen Kai-Fu Tang

We have shown that Dicer processes 7SL RNA into different fragments ranging from ∼20 to more than 200 nucleotides. Here we addressed the molecular functions of these 7SL RNA fragments and found that some of them functioned as dominant-negative regulators of the full-length 7SL RNA, interfering with signal recognition particle (SRP) complex formation. Transfection of these 7SL RNA fragments inhi...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Edward M Kennedy Adam W Whisnant Anand V R Kornepati Joy B Marshall Hal P Bogerd Bryan R Cullen

Although RNA interference (RNAi) functions as a potent antiviral innate-immune response in plants and invertebrates, mammalian somatic cells appear incapable of mounting an RNAi response and few, if any, small interfering RNAs (siRNAs) can be detected. To examine why siRNA production is inefficient, we have generated double-knockout human cells lacking both Dicer and protein kinase RNA-activate...

Journal: :RNA 2007
Noah C Welker Jeffrey W Habig Brenda L Bass

We describe the first microarray analysis of a whole animal containing a mutation in the Dicer gene. We used adult Caenorhabditis elegans and, to distinguish among different roles of Dicer, we also performed microarray analyses of animals with mutations in rde-4 and rde-1, which are involved in silencing by siRNA, but not miRNA. Surprisingly, we find that the X chromosome is greatly enriched fo...

2012
Byeong-Moo Kim Marc-Christian Thier Sangnam Oh Richard Sherwood Chryssa Kanellopoulou Frank Edenhofer Michael Y. Choi

MicroRNAs play a pivotal role in cellular maintenance, proliferation, and differentiation. They have also been implicated to play a key role in disease pathogenesis, and more recently, cellular reprogramming. Certain microRNA clusters can enhance or even directly induce reprogramming, while repressing key proteins involved in microRNA processing decreases reprogramming efficiency. Although micr...

Journal: :Science 2006
Ian J Macrae Kaihong Zhou Fei Li Adrian Repic Angela N Brooks W Zacheus Cande Paul D Adams Jennifer A Doudna

The specialized ribonuclease Dicer initiates RNA interference by cleaving double-stranded RNA (dsRNA) substrates into small fragments about 25 nucleotides in length. In the crystal structure of an intact Dicer enzyme, the PAZ domain, a module that binds the end of dsRNA, is separated from the two catalytic ribonuclease III (RNase III) domains by a flat, positively charged surface. The 65 angstr...

Journal: :Mechanisms of Development 2008
Savitha Kalidas Charcacia Sanders Xuecheng Ye Tamara Strauss Mary Kuhn Qinghua Liu Dean P. Smith

The miRNA pathway has been shown to regulate developmentally important genes. Dicer-1 is required to cleave endogenously encoded microRNA (miRNA) precursors into mature miRNAs that regulate endogenous gene expression. RNA interference (RNAi) is a gene silencing mechanism triggered by double-stranded RNA (dsRNA) that protects organisms from parasitic nucleic acids. In Drosophila, Dicer-2 cleaves...

2010

MicroRNAs (miRNAs) are non-coding small RNAs that regulate eukaryotic gene activity at the post-transcriptional level by a process termed miRNA gene suppression. MicroRNA-122 (miR-122) is predominantly expressed in human liver cells and recent studies indicated that miR-122 promotes Hepatitis C Virus (HCV) replication and translation through physical interaction with two tandem binding sites lo...

Journal: :Current Biology 2006
Thomas Andl Elizabeth P. Murchison Fei Liu Yuhang Zhang Monica Yunta-Gonzalez John W. Tobias Claudia D. Andl John T. Seykora Gregory J. Hannon Sarah E. Millar

The discovery that microRNAs (miRNAs) play important roles in regulating gene expression via posttranscriptional repression has revealed a previously unsuspected mechanism controlling development and progenitor-cell function (reviewed in ); however, little is known of miRNA functions in mammalian organogenesis. Processing of miRNAs and their assembly into the RNA-induced silencing (RISC) comple...

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