Use of medicinal plants for attenuation of hyperglycemia and restoration of lipids disorder to normal level is clinically very important. The aim of present study was to evaluate the effects of Berberis integerrima Bge. fruit aqueous extract (BIFAE) on blood glucose and lipid profile in streptozotocin (STZ) - induced diabetic rats. The STZ-induced diabetic rat were treated by fruit aqueous extr...

Defective glucose utilization in the liver of the glucose-fed diabetic rat has been stated to be the result of at least two blocks: one, at an early stage in glycolysis, probably hexokinase; the other, in the synthesis of fatty acids from the Z-carbon-like intermediate. This conclusion was based on the following observations: (1) the conversion of C14-glucose to CO2 was depressed in the liver o...

The present work examined ex vivo the acute effect of quercetin on diabetic rat aortic ring reactivity in response to endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) relaxants, and to the alpha(1)-adrenergic agonist phenylephrine (PE). Responses were compared to those of aortic rings from age- and sex-matched euglycemic rats. Compared to euglyc...

objective(s) since diabetes mellitus is accompanied by cognitive impairment in diabetic patient and animal models and since lipids play important roles in neuronal membrane composition, structure and function; we intended to evaluate the effect of dietary butter oil on passive avoidance memory of streptoztosin (stz)-induced diabetic rats in this study. materials and methods thirty six adult mal...

The study was undertaken to determine whether the phenomenon of endothelium-dependent relaxation was impaired in the spontaneously diabetic BB Wistar rat. Endothelium-dependent relaxation in the aorta of overtly diabetic animals was compared with that in nondiabetic BB rats. The relaxative responses were elicited in vitro to acetylcholine (-8.0 to -5.5 log M) and histamine (-7.0 to -3.0 log M) ...

BACKGROUND Diminished calcium (Ca2+) transients in response to physiological agonists have been reported in vascular smooth muscle cells (VSMCs) from diabetic animals. However, the mechanism responsible was unclear. METHODOLOGY/PRINCIPAL FINDINGS VSMCs from autoimmune type 1 Diabetes Resistant Bio-Breeding (DR-BB) rats and streptozotocin-induced rats were examined for levels and distribution ...

Defective glucose utilization in the liver of the glucose-fed diabetic rat has been stated to be the result of at least two blocks: one, at an early stage in glycolysis, probably hexokinase; the other, in the synthesis of fatty acids from the Z-carbon-like intermediate. This conclusion was based on the following observations: (1) the conversion of C14-glucose to CO2 was depressed in the liver o...

The Bio Breeding/Worcester (BB/W) rat develops spontaneous insulin-dependent diabetes mellitus secondary to lymphocytic infiltration and destruction of the pancreatic beta-cells. This destructive process in the pancreas has been postulated to be based on a thymus-dependent cell-mediated autoimmune process. In view of the well recognized association in man of diabetes mellitus and another autoim...

background neuropathy is one of the most complications of diabetes that may be associated with changes in the structure and function of the basement membranes in nerves. laminin is one of the most important components of basement membranes in sciatic nerve. objectives in this study, the protective effects of alpha lipoic acid (ala) as an antioxidant agent on blood glucose level, body weight and...