Diabetic polyneuropathy is a major complication of diabetes mellitus, causing severe alterations of the neural circuits between spinal nerves and spinal cord. The analysis of 3D confocal images of dorsal root ganglia in diabetic mice, where different fluorescent markers are used to identify different types of nociceptors, can help understanding the unknown mechanisms of this pathology. Neverthe...

Diabetic peripheral neuropathy is a common complication of diabetes. It presents as a variety of syndromes for which there is no universally accepted unique classification. Sensorimotor polyneuropathy is the most common type, affecting about 30% of diabetic patients in hospital care and 25% of those in the community. Pain is the reason for 40% of patient visits in a primary care setting, and ab...

Objective. To study the content of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor type B kinase (TrkB) in patients at an early stage diabetic polyneuropathy. Late diagnosis polyneuropathy (DPN) is largely due to presence a subclinical stage, which damage nervous system develops absence complaints from patient.
 Materials methods. 64 with 2 diabetes mellitus 11 persons co...

Vitamin D deficiency has been associated with both type 1 and type 2 diabetes as well as both the microvascular and macrovascular complications of diabetes. Vitamin D deficiency has been shown to be more common in diabetic patients who have symptoms of distal symmetrical polyneuropathy. In addition, vitamin D deficiency has been associated with a lower pain threshold which increases when vitami...