We investigated the pharmacokinetics of piperacillin and tazobactam in the extracellular space fluid of inflamed soft tissues of six patients with diabetic foot infection using in vivo microdialysis and found similar penetration for piperacillin but not for tazobactam into inflamed and noninflamed soft tissue.

Aim: Diabetic foot ulcers are the most common cause of nontraumatic lower extremity amputations in the industrialized world. Tissue-engineering products offer a lower extremity salvage strategy when healing does not proceed according to the standard of care. New allogeneic sheets are available for the management of diabetic leg and foot ulcers. Methods: The endpoints of this case series study r...

Diabetic foot ulcers are the consequence of multiple factors including peripheral neuropathy, decreased blood supply, high plantar pressures, etc., and pose a significant risk for morbidity, limb loss and mortality. The critical aspects of the wound healing mechanism and host physiological status in patients with diabetes necessitate the selection of an appropriate treatment strategy based on t...

AIM To assess feelings of powerlessness in patients with either venous or diabetic foot ulcers. METHODS This was an exploratory, descriptive, cross-sectional study conducted from May 2010 to August 2012. Two hundred adult patients with either venous leg ulcers (N=100) or diabetic foot ulcers (N=100) were consecutively recruited from an outpatient wound care clinic of a university hospital in ...

INTRODUCTION Charcot foot is a severe complication to diabetes mellitus and treatment involves several different clinical specialities. Our objective was to describe the current awareness, knowledge and treatment practices of Charcot foot among doctors who handle diabetic foot disorders. METHODS This study is based on a questionnaire survey sent out to healthcare professionals, primarily doct...

OBJECTIVE To examine the relationships among muscle weakness, foot deformities, and peroneal and tibial nerve conduction velocity in diabetic and nondiabetic men. RESEARCH DESIGN AND METHODS A neuropathic and foot evaluation was undertaken in 10 nondiabetic control subjects (group C) and in 36 consecutive diabetic patients attending Diabetes Centre clinics, including 10 diabetic control subje...

BACKGROUND Diabetes related foot disease is a major cause of morbidity and mortality in people with diabetes. This is despite the fact that interventions to reduce the burden of diabetic foot disease are estimated to be highly cost effective, even cost saving in both developed and developing countries. This exploratory qualitative study was undertaken in a developing country known to have a ver...

A 49-year-old male patient with type 2 diabetes mellitus and Diabetic Foot Syndrome (DFS) was evaluated by comprehensive diabetic foot assessment. 10-session photobiomodulation therapy (low-level laser therapy) prescribed for neuropathic pain symptoms applying the scanning probe method. Customized insoles were recommended redistributing plantar pressures reducing stress on foot’s surface 4 week...

Proper foot and nail management is essential to maintaining a good quality of life and remaining independent as we age. Basic and ongoing care of the feet and proper shoe selection are critical not only for preventing diabetic foot problems, but also for helping to lead productive, balanced lives. When our feet hurt, the rest of our body most likely hurts too. Because proper foot and nail care ...

Patients with diabetes may present with an array of foot disorders that include, but are not limited to, neuropathy, ulceration, and osteomyelitis. Ischemia and infection are common clinical concerns as either, or both, may be involved in the pathogenesis of these disorders. Management choices can be difficult to make and diagnostic imaging is often sought to help clarify the clinical picture. ...