BACKGROUND Phthalates are a group of environmental endocrine disruptors and have been ubiquitously applied in industrial field. Few studies had investigated how dietary intake was related with phthalate body burden in children. To determine the relationship between phthalate body burden and dietary intake among school age children in Shanghai, China. METHODS Four hundred and thirty schoolchil...

OBJECTIVES This study was conducted to assess inter-species and inter-individual differences in the metabolism of di(2-ethylhexyl)phthalate (DEHP) in humans and mice. METHODS The activities of four DEHP-metabolizing enzymes [lipase, UDP-glucuronocyltransferase (UGT), alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH)] were measured in the livers of 38 human subjects of various ages an...

The International Agency for Research on Cancer classified the di-2-ethylhexyl phthalate (DEHP) as "possibly carcinogenic to humans". In vitro studies reported that phthalate exposure resulted in induction of several nuclear transcription factors that are activators of telomerase reverse transcriptase (TERT) and telomerase activity of the human telomerase complex. The objective of this study wa...

Information about the distribution of chemical-production mass with respect to use and release is a major and unavailable input for calculating population-scale exposure estimates. Based on exposure models and biomonitoring data, this study evaluates the distribution of total production volumes (and environmental releases if applicable) for a suite of organic compounds. We used Bayesian approac...

Phthalates are materials with a wide spectrum of industrial applications. High molecular weight phthalates are primarily used as plasticizers in the manufacture of flexible vinyl. Low molecular weight phthalates are used in personal-care products, as solvents for cellulose acetate, and in making lacquers, varnishes, and coatings [1]. A quarter of the plasticizers produced are made of di-(2-ethy...

Phthalates and bisphenol A are environmental endocrine-disrupting chemicals used widely in common consumer products. There is increasing concern about human exposure to phthalates and bisphenol A due to the potential adverse effects related to the anti-androgenic activity of phthalates and estrogenic activity of bisphenol A. In assessing environmental exposure to phthalates and bisphenol A, it ...

Background/Aim: Animal studies have shown that endocrine-disrupting chemicals can cause transient hypothyroidism. The aim of this study is to investigate the effects exposure endocrine disrupting (polychlorinated biphenyls (PCBs), polybrominated (PBBs), bisphenol A (BPA) in plastics) intrauterine life on thyroid function tests during neonatal period. Methods: In observational cohort study, cord...

Exposure to di-(2-ethylhexyl) phthalate (DEHP) is prevalent based on the measurement of its hydrolytic metabolite mono-(2-ethylhexyl) phthalate (MEHP) in the urine of 78% of the general U.S. population studied in the 1999-2000 National Health and Nutrition Examination Survey (NHANES). However, despite the high level of production and use of DEHP, the urinary MEHP levels in the NHANES samples we...

The absorption of undiluted phthalate diesters [dimethyl phthalate (DMP), diethylphthalate (DEP), dibutyl phthalate (DBP) and di-(2-ethylhexyl)phthalate (DEHP)] has been measured in vitro through human and rat epidermal membranes. Epidermal membranes were set up in glass diffusion cells and their permeability to tritiated water measured to establish the integrity of the skin before the phthalat...

The paper presents two methods for determination of phthalates in polymer materials. The methods compared were gas chromatography combined with the mass spectrometry (GC/MS) and gas chromatography with electron capture detector (GC/ECD). The GC/ECD technique was chosen for this comparison, because the ECD detector was one of few capable of detecting phthalates. In both cases the same procedure ...