The miR-17-92a cluster, also known as 'oncomiR-1', is an RNA transcript that plays a pivotal regulatory role in cellular processes, including the cell cycle, proliferation and apoptosis. Its dysregulation underlies the development of several cancers. Oncomir-1 comprises six constituent miRNAs, each processed with different efficiencies as a function of both developmental time and tissue type. T...

MicroRNAs (miRNAs) regulate cardiovascular biology and disease, but the role of flow-sensitive microRNAs in atherosclerosis is still unclear. Here we identify miRNA-712 (miR-712) as a mechanosensitive miRNA upregulated by disturbed flow (d-flow) in endothelial cells, in vitro and in vivo. We also show that miR-712 is derived from an unexpected source, pre-ribosomal RNA, in an exoribonuclease-de...

microRNAs (miRNAs) are a large family of 21- to 22-nucleotide non-coding RNAs that interact with target mRNAs at specific sites to induce cleavage of the message or inhibit translation. miRNAs are excised in a stepwise process from primary miRNA (pri-miRNA) transcripts. The Drosha-Pasha/DGCR8 complex in the nucleus cleaves pri-miRNAs to release hairpin-shaped precursor miRNAs (pre-miRNAs). Thes...

1. General Medical council, UK. Regulating doctors, ensuring good medical practice [internet]. London: GMc; c2014 [cited 2014 Mar 11]. Available from: http://www.gmc-uk.org/concerns/complaints_and_role_of_the_gmc.asp (accessed on 25 February 2014) 2. Pandya SK. Medical council of india: the rot within. Indian J Med Ethics 2009 Jul–Sep;6(3):125–31. 3. Pasha S. The spectre of Desai. India Today [...

miRNAs são moléculas endógenas de 19 a 25 nucleotídeos, essas transcritas pela RNA polimerase II, após transcrição, os microRNAs processados por uma RNAse III chamada DROSHA e proteína ligação ao dupla fita DGCR8; DICER se associa com TRBP (proteína responsiva ativação gênica) na clivagem do duplex miRNA, as proteínas complexo silenciamento induzido RISC ocasionando regulação negativa pós-trans...

Small RNAs play crucial roles in regulating gene expression during mammalian meiosis. To investigate the function of microRNAs (miRNAs) and small interfering RNAs (siRNAs) during meiosis in males, we generated germ-cell-specific conditional deletions of Dgcr8 and Dicer in mice. Analysis of spermatocytes from both conditional knockout lines revealed that there were frequent chromosomal fusions d...

This paper deals with the history of Density-Wave Spiral Theories in the 1960s. The motivation to write the paper was the publication of two papers on the history of these theories (Pasha 2004a, b). Pasha's papers tell only a part of the story that took place on the Western side of the Iron Curtain in the 1960s. But giving only a part of the full story is a distortion of historical truth. Impor...

Fuzzy regression analysis using fuzzy linear models with symmetric triangular fuzzy number coefficient has been introduced by Tanaka et al. The goal of this regression is to find the coefficient of a proposed model for all given input-output data sets. In this paper, we propose a new 1716 E. Pasha et al method for computation of fuzzy regression. The method is constructed on the basis of minimi...