This study aimed to develop spectrophotometry method using area under curve determine the levels of dextromethorphan HBr (DMP), doxylamine succinate (DOX) and pseudoephedrine HCl (PSE) in tablet dosage form ethanol as solvent. The is based on AUC absorption measurement wavelength ranges 273-283 nm for DMP, 262-272 DOX 251-261 PSE. Then, was applied PSE form. selection wavelengths gives best res...

There is an error in the third sentence of the second paragraph of the " Subjects and treatment " subsection of the Methods. The correct sentence is: According to the study design, which also designated phenotyping for CYP2D6, 10 mg dextromethorphan in water (DEX, as dextrome-thorphan hydrobromide monohydrate, Fagron, Barsbüttel, Germany) had been administered simultaneously. article distribute...

Dextromethorphan (DM) is a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, which is widely used as an antitussive agent. DM also prevents neuronal damage and modulates pain sensation via noncompetitive antagonism of excitatory amino acids (EAAs). DM has been found to be useful in the treatment of pain in cancer patients and in the treatment of methotrexate-induced neurotoxicity....

Reports of rapid-onset but short-duration antidepressant effects in patients with treatment-resistant mood disorders after intravenous administration of ketamine have prompted efforts to find an agent with ketamine's properties that can be administered orally in repeated doses in order to sustain that action. One candidate for this dextromethorphan, and here the pharmacologic mechanism of actio...

We tested the hypothesis that the polymorphic enzyme CYP2D6 is related to nicotine metabolism in 261 healthy subjects enrolling in a smoking cessation clinic. Subjects completed a questionnaire, were given dextromethorphan, and contributed a urine and blood sample. The CYP2D6 phenotype (based on a determination of dextromethorphan and metabolites in an aliquot of overnight urine) and genotype (...

Involuntary emotional expression disorder (IEED) is syndrome characterized with relatively stereotypical episodes of uncontrollable crying and/or laughing. Additionally, this syndrome can include irritability, anger and frustration. This syndrome is common among a number of neurologic diseases like patients with a stroke or traumatic brain injury (TBI), patients with amyotrophic lateral scleros...