The uptake and degradation of ‘251-labeled human plasma low density lipoprotein (lZ51-LDL) by mouse peritoneal macrophages was increased markedly by the addition of high molecular weight dextran sulfate (Mr = 500,000) to the incubation medium. The dextran sulfate and the ‘%LDL formed a complex that was taken up and degraded with saturation kinetics, suggesting a requirement for a specific surfa...

Lecithin and lecithin/cholesterol dispersions as well as lysolecithin micelles were used to provide basic information on the mechanism of the interaction of zwitterionic phospholipids with dextran sulfate. The addition of dextran sulfate to lecithin dispersions or lysolecithin micelles in the presence of Ca2+ produced insoluble complexes. At each Ca2+ concentration, the amount of insoluble comp...