The uptake and degradation of ‘251-labeled human plasma low density lipoprotein (lZ51-LDL) by mouse peritoneal macrophages was increased markedly by the addition of high molecular weight dextran sulfate (Mr = 500,000) to the incubation medium. The dextran sulfate and the ‘%LDL formed a complex that was taken up and degraded with saturation kinetics, suggesting a requirement for a specific surfa...
