The objective of this study was to design and prepare a new contrast agent of magnetic resonance (MR) imaging for the evaluation of therapeutic angiogenesis. Diethylenetriaminepentaacetic acid (DTPA) residue of a chelator was chemically introduced to dextran with a molecular weight of 74,000 (dextran-DTPA). Cyclic peptide containing an arginine-glycine-aspartic acid (RGD) sequence (cyclic RGD) ...

A method is described for the estimation of serum haptoglobin as ;haemoglobin-binding capacity'. The method relies on column chromatographic separation of the haemoglobin/haptoglobin complex from excess added free haemoglobin on the dextran gel Sephadex G.100. The method is simple and reproducible, and correlates well with another method of estimating haemoglobin-binding capacity over a wide ra...

Cationic polymeric nanoparticles have great potential for developing drug delivery systemswith limited side effects for tumor medication. The goal of this research is investigation ofcationic dextran-spermine polymer (DS) efficacy for improvement of hydrophilic drug deliveryto negatively charged cancerous cells. Capecitabine (as a hydrophilic antineoplastic drug) wasloaded into the magnetic dex...

This reviewed work on the development of photosensitive nanoparticles (NPs) based a photodegradable poly(o-nitrobenzyl acrylate) core (PNBA, hydrophobic and biocompatible polymer) dextran-derived shell (dextran is biodegradable water-soluble bacterial polysaccharide). First, methods for synthesizing PNBA-N3 were demonstrated by 1) single electron transfer radical polymerization (SET-LRP) o-nitr...

Background and aimsThe accumulation of adipose tissue macrophages (ATMs) in obesity has been associated with hepatic injury. However, the ATMs contribution to fibrosis non-alcoholic fatty liver disease (NAFLD) remains be elucidated. Herein, we investigate relationship between NAFLD patients evaluate impact modulation over an experimental NASH model.MethodsAdipose biopsies from 42 different stag...

PURPOSE To assess the effects of retro-orbital (RO) injection of fluorescein isothiocyanate dextran (FITC-dextran) for observing mouse retinal vessels. METHODS Oxygen-induced retinopathy (OIR) was induced in 7-day postnatal (P7) C57BL/6J mice by exposing them to a 75% oxygen atmosphere for 5 days and then returning them to room air at P12. At P17, 45 P17 OIR mice and 12 normal mice received a...

Both proteins and polysaccharides are biopolymers present on a bacterial surface that can simultaneously affect bacterial adhesion. To better understand how the combined presence of proteins and polysaccharides might influence bacterial attachment, adhesion forces were examined using atomic force microscopy (AFM) between colloids (COOH- or protein-coated) and polymer-coated surfaces (BSA, lysoz...

We have compared the effects of an increase in perfusate viscosity induced by dextran and by hematocrit (Hct) on segmental vascular resistance in the pulmonary circulation and the effect of flow on microvascular resistance in lungs perfused with dextran and red blood cells. We isolated and perfused lungs of 39 neonatal rabbits weighing 670 +/- 250 g. To determine the effect of dextran, group 1 ...

The antigenicity of a number of different intravenous iron preparations was tested by reverse single radial immunodiffusion with antidextran antibodies. The tested products are low molecular weight iron dextran, ferumoxytol, iron isomaltoside 1000, sodium ferric gluconate, iron sucrose, and ferric carboxymaltose. Dextran-induced anaphylactic reactions have been clinically observed with low mole...