A 19-year-old woman had a Mirena intrauterine system (IUS) fitted for contraception 10 weeks postnatally. She attended our clinic 4 weeks later and reported apparent migraine with aura, which had developed within a few days of the fitting. Initially, she tried paracetamol and ibuprofen, which were not helpful, and saw her general practitioner who prescribed a triptan. The headaches were becomin...

BACKGROUND Hirsutism occurs in 5% to 10% of women of reproductive age when there is excessive terminal hair growth in androgen-sensitive areas (male pattern). It is a distressing disorder with a major impact on quality of life. The most common cause is polycystic ovary syndrome. There are many treatment options, but it is not clear which are most effective. OBJECTIVES To assess the effects of...

Although oxylipins can be synthesized from free fatty acids, recent evidence suggests that oxylipins are components of plastid-localized polar complex lipids in Arabidopsis (Arabidopsis thaliana). Using a combination of electrospray ionization (ESI) collisionally induced dissociation time-of-flight mass spectrometry (MS) to identify acyl chains, ESI triple-quadrupole (Q) MS in the precursor mod...

Context: Insulin resistance could be associated with decreased GLP-1 secretion in PCOS. Treatment with oral contraceptives (OCP) and/or metformin (M) may affect GLP-1 levels and the increased risk of reactive hypoglycaemia (RH) in PCOS. Setting: Outpatient clinic. Patients and interventions: Randomized, controlled clinical trial. 90 patients with PCOS were randomized to 12 month treatment with ...

Venous thromboembolism (VTE) is responsible for more than half a million deaths annually in the European Union, most in older people following surgery, but some in women of reproductive age using various hormonal contraceptives. In some parts of the population inherited defects of the blood coagulation system (factor V Leiden, prothrombin G20210A, protein C, protein S and antithrombin deficienc...

The treatment of polycystic ovary syndrome (PCOS) is based on the patient's presenting symptoms and any significant abnormal findings. Symptoms can be managed with combined oral contraceptives (OCs), insulin-sensitizing agents, antiandrogens, and medications used to induce ovulation. Here we detail the various treatment options. We also discuss screening for and monitoring of the long-term heal...

Postmenopausal osteoporosis can be prevented by use of antiresorptive agents, but how the individual response to therapy should be monitored has not yet been settled [1]. Because the concentrations of markers of both bone resorption and formation are 50-100% greater in postmenopausal women than in premenopausal women, and decrease by the same magnitude after a few months of antiresorptive thera...

l-a-Acetyl-N-normethadol (nor-LAAM) and l-a-acetyl-N,N-dinormethadol (dinor-LAAM) are active metabolites of the opiate l-a-acetylmethadol (LAAM), and they contribute to the prolonged actions of the parent compound. Single doses of nor-LAAM, dinor-LAAM, LAAM, methadone and morphine were given intravenously to the chronic spinal dog to determine acute, singledose effects and their ability to supp...

The reduction of the triple bond and carbonyl group of an , ketoalkyne, 4-phenyl-3-butyn-2-one (PBYO), by rat liver microsomes and cytosol was investigated. The triple-bond-reduced product trans-4-phenyl-3-buten-2-one (PBO) and the carbonyl-reduced product 4-phenyl-3-butyn-2-ol (PBYOL) were formed when PBYO was incubated with rat liver microsomes in the presence of NADPH. The triple bond of 1-p...

Recently, there has been a growing controversy, especially among evangelicals, over whether the birth control pill might have an abortifacient mechanism that sometimes causes early chemical abortions. An understanding of this controversy necessitates a clear definition of abortion, abortifacient, pregnancy, implantation, and especially personhood. If a zygote (fertilized egg) is not a person, t...