We identify three properties of the standard oncology Phase I trial design or 3 + 3 design. We show that the standard design implicitly uses isotonic regression to estimate a maximum tolerated dose. We next illustrate the relationship between the standard design and a Bayesian design proposed by Ji et al. (2007). A slight modification to this Bayesian design, under a particular model specificat...

A new 3-D solenoid-inductor structure that is compatible with standard CMOS technology is proposed. Simulation shows excellent area efficiency of more than 80% saving over conventional planar spiral inductor. If combined with post-micromaching, a peak quality factor greater than 10 at 30GHz can be realized.

A standard cell library typically contains several versions of any given gate type, each of which has a di erent gate size. We consider the problem of choosing optimal gate sizes from the library to minimize a cost function (such as total circuit area) while meeting the timing constraints imposed on the circuit. After presenting an e cient algorithm for combinational circuits, we examine the pr...

Wide diffusion of methodologies and software relevant to Product Lifecycle Management (PLM) in industrial companies faces heterogeneity of IT systems. Especially, the lack of interoperability between Product Data Management (PDM) systems, that drive virtual product development, and Enterprise Resource Planning (ERP), which manages real product, cannot lead to a coherent description of the produ...

The Technological Center CARTIF has carried out a successful pilot project for the implementation of the Spanish Standard UNE 150301:2003 “Environmental Management of the process of design and development. Eco-design”. The implementation was developed during the year 2004 in six SMEs of Castilla y León (Northwest Spain). The Spanish Standard UNE 150301:2003 [1] establishes the requirements of a...

The introduction of non-coded amino acids with well defined stereochemical and functional properties will greatly enhance the scope of protein design and engineering. The present state of methodologies for incorporation of non-coded residues into proteins is examined. The prospects for conformationally constrained amino acid residues are evaluated in the light of peptide structural studies. Tem...

The submicron regime has caused the interconnect delay to become a critical determiner of circuit performance. As a result, circuit placement is starting to play an important role in today's high performance chip designs. In addition to wirelength optimization, the issue of reducing excessive congestion in local regions such that the router can finish the routing successfully is becoming anothe...

Recent efforts in the design of wireless RF transceivers focus on high integration and multi-standard operation. Higher integration can be obtained by using receiver architectures, such as wide-band IF with double conversion (WIF), that perform channel select filtering on-chip at baseband. Performing this baseband channel select filtering in the digital domain allows for the programmability nec...

Using a single maskless postprocessing step we have developed an accelerometer in a standard commercial CMOS process capable of a sensitive axis parallel or perpendicular to the die surface. Our postprocess is realized using xenon difluoride (XeF2) as a bulk etchant. The combination of this etchant and the standard CMOS process allows realization of cantilevers with piezoresistive sensors in al...

Nowadays, it is a matter of fact that a “one-size-fit-all” methodology or design process useful and fitting every kind of problem, situation, or design context does not exist. (Situational) Method Engineering (SME) discipline aims at determining techniques and tools for developing ad hoc design methodologies. SME mainly and highly focuses on the reuse of portion of existing design processes or ...