A Dermatofibroma B Merkel cell carcinoma C Epidermoid cyst History Mrs. B. is a 67-year-old Caucasian female. She is married, works as a housewife, and has two grown children. She denies alcohol or tobacco use. Her medical history includes hy-pertension and poorly controlled insulin dependent type 2 diabetes mel-litus. She reports a history of frequent sunbathing from her early teens until she ...

Mechanism of Action Liquid nitrogen, which boils at −196°C (−320.8°F), is the most effective cryogen for clinical use. It is particularly useful in the treatment of malignant lesions. Temperatures of −25°C to −50°C (−13°F to −58°F) can be achieved within 30 seconds if a sufficient amount of liquid nitrogen is applied by spray or probe. Generally, destruction of benign lesions requires temperatu...

The Malignant melanoma is an uncommon primary malignant tumour of the foot.1 It occurs in different forms like superficial spreading, nodular, lentiginous and acral. Amelanotic/ hypomelanotic melanoma is a non-pigmented variety of cutaneous melanoma accounting for 2-8% of all primary melanomas.2,3 The lesion is usually exophytic and ulcerative with or without metastasis. The lesions usually beg...

In their elegantly designed and executed study on training for skin tumour triage primary-care physicians (PCPs),1 Harkemanne et al. highlight what is arguably obvious: Any structured in dermatoscopy PCPs likely to be beneficial. This study, involving 216 PCPs, 40% trainees, 87% younger than 46 years 73% female, was adequately powered, rendering statistically significant findings. The methods w...

BACKGROUND Benign and malignant fibrous histiocytoma present with a considerable difference concerning cellular organization in their vicinity. OBJECTIVE Normally appearing epithelium covers the malignant form in contrast to hyperplastic epidermis for benign tumors. It is an open question as to whether the tumor-associated fibroblasts are capable to affect phenotypic features of normal kerati...

A 70-year-old male presented with an asymptomatic slowly growing brownish nodular lesion involving the left ear. The patient had noticed a rapid growth of the lesion in the previous 3 months. A biopsy followed by wide excision was performed. The biopsy consisted of a piece of skin measuring 1 cm with a firm dermal lesion. Microscopic examination showed a skin with basal cell carcinoma (Fig. 1) ...

Meyerson phenomenon (MP) is characterized by a symmetrical area of erythema and scales encircling a central lesion, which is most commonly a banal melanocytic nevus. Herein, we describe an unusual case with MP representing an eczematized response to a melanoma in situ and review the literature covering this entity. A 56-year-old man presented with a 6-month history of a pruritic, pigmented lesi...

Dear Editor, Cutaneous metastases (CM) are detected in about 0.6-10.4% of patients with an internal malignancy (1-3). Excluding melanoma, breast and lung carcinomas are the main source of CM in women and men, respectively (1,4,5). CM can have different clinical features, and a diagnosis of CM is usually suspected before performing a biopsy. However, this can be a pitfall for clinicians when the...