Four interesting sequoiatones stereoisomers (1-4) were isolated from a wetland soil-derived fungus Talaromyces flavus by chiral HPLC. On the basis of comprehensive NMR and mass analyses, their planar structures were elucidated as the same as that of sequoiatone B. Among them, 1 and 3 (or 2 and 4) were a pair of enantiomers, and 1 and 2 (or 3 and 4) were a pair of stereoisomers with epimerizatio...

für Naturforschung in cooperation with the Max Planck Society for the Advancement of Science under a Creative Commons Attribution 4.0 International License. Dieses Werk wurde im Jahr 2013 vom Verlag Zeitschrift für Naturforschung in Zusammenarbeit mit der Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. digitalisiert und unter folgender Lizenz veröffentlicht: Creative Commons Namen...

A computer-readable dictionary for protein structure refinement is presented. The dictionary is based on the set of interatomic bonds and bond angles previously derived from small-molecule structures by Engh & Huber [Acta Cryst. (1991), A47, 392-400]. The internal inconsistency of the set is discussed. Some preliminary results derived from several protein structures refined at atomic resolution...

this paper presents optimal control method to path planning of mobile robots with flexible joints. dynamic equations are derived and additional kinematic constraints are used to solve the extra dofs arose from base mobility. then with modeling the elasticity at each joint as a linear torsinal spring, the set of equations are formed. the hamiltonian function is formed and the necessary condition...

background: in radiation therapy, water is the phantom material of choice, both for reference and for relative dosimetry measurements. solid phantoms, however, are more useful for routine measurements because they tend to be more robust and easier to set up than water phantoms. materials and methods: fluka input data cards have been arranged in sequential order. a simple cylindrical geometry wi...

global health research is essentially a normative undertaking: we use it to propose policies that ought to be implemented. to arrive at a normative conclusion in a logical way requires at least one normative premise, one that cannot be derived from empirical evidence alone. but there is no widely accepted normative premise for global health, and the actors with the power to set policies may use...

BACKGROUND The 5-level version of the EQ-5D (EQ-5D-5L) was recently developed. A number of preference-based scoring systems are being developed for several countries around the world. OBJECTIVE To develop a value set for the EQ-5D-5L based on societal preferences in Canada. METHODS We used age, sex, and education quota sampling from the general population from 4 cities across Canada. Compos...