نتایج جستجو برای: derived growth factor α

تعداد نتایج: 1974380  

Journal: :Journal of Biological Chemistry 1989

Abdolamir Allameh, Maryam Jazayeri Masoud Soleimani, Saeid Kaviani Seyed Hamid Jazayeri Somaieh Kazemnejad

Human bone marrow derived mesenchymal stem cells (HBMSCs) have the potential to differentiate into cells such as adipocyte, osteocyte, hepatocyte and endothelial cells. In this study, the differentiation of hBMSCs into endothelial like-cells was induced in presence of vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF-1). The differentiated endothelial cells were exam...

2017
Lalita Subedi Ramu Venkatesan Sun Yeou Kim

Allyl isothiocyanate (AITC), present in Wasabia japonica (wasabi), is an aliphatic isothiocyanate derived from the precursor sinigrin, which is a glucosinolate present in vegetables of the Brassica family. Traditionally, it has been used to treat rheumatic arthralgia, blood circulation, and pain. This study focuses on its anti-apoptotic activity through the regulation of lipopolysaccharide (LPS...

Journal: :Cardiovascular research 2005
Alexander Levitzki

The clogging of arteries by neointima is a hallmark of atherosclerosis and of restenosis following balloon angioplasty. The realization in the 1980s that PDGF and its receptor play a key role in the onset of neointimal formation led us to develop PDGFR kinase inhibitors as antirestenosis agents. In this review, we describe the development of these inhibitors and their implementation as antirest...

Journal: :Cancer research 2009
Joydeep Mukherjee Deepak Kamnasaran Anand Balasubramaniam Ivan Radovanovic Gelareh Zadeh Tim-Rasmus Kiehl Abhijit Guha

Schwannomas, although benign, can be fatal or give rise to significant morbidity due to an unpredictable growth rate. They can reoccur after surgery or radiation, current treatments each with significant inherent risks. These risks are further amplified in neurofibromatosis type 2 (NF2), a germ line predisposition syndrome characterized by multiple schwannomas, underlying the need for biologica...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2015
Martin J J Ronis Kelly E Mercer Brenda Gannon Bridgette Engi Piotr Zimniak Colin T Shearn David J Orlicky Emanuele Albano Thomas M Badger Dennis R Petersen

To test the significance of lipid peroxidation in the development of alcoholic liver injury, an ethanol (EtOH) liquid diet was fed to male 129/SvJ mice (wild-type, WT) and glutathione S-transferase A4-4-null (GSTA4-/-) mice for 40 days. GSTA4-/- mice were crossed with peroxisome proliferator-activated receptor-α-null mice (PPAR-α-/-), and the effects of EtOH in the resulting double knockout (dK...

Journal: :Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 2005
D Olivares J P Gisbert J M Pajares

NF-κB: nuclear factor κB; TNF-α: tumor necrosis factor α; DD: death domain; FADD: Fas-associated death domain; FasL: Fas receptor ligand; TNFR: TNF receptor; TRADD: TNFR-associated death domain; TRAF: TNFR-associated factor; COX: cyclooxygenase; PG: prostaglandin; iNOS: inducible nitric oxide synthase; NO: nitric oxide; MDR-1: multiple drug resistance gene; IL: interleukin; EGF: epithelial grow...

Journal: :Cancer research 2007
Gudrun Reiterer Andrew Yen

Here, we show that the platelet-derived growth factor receptor (PDGFR) regulates myeloid and monocytic differentiation of HL-60 myeloblastic leukemia cells in response to retinoic acid (RA) and vitamin D3 (D3), respectively. Both RA and D3 decreased the expression of PDGFR-alpha and PDGFR-beta throughout differentiation. When cells were treated with the PDGFR inhibitor AG1296 in addition to RA ...

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