The tert-butyloxycarbonyl (Boc) group is one of the most widely used amine-protecting groups in multistep reactions synthetic organic chemistry as well peptide synthesis. Traditional methods to remove Boc have disadvantages terms high acidity, use expensive reagents, excessive amounts catalysts and harmful solvents temperatures, making them environmentally unsustainable. Therefore, more efforts...

Front Cover: Caffeic acid is a component of coffee beans and bears catechol functionality. In article number 2100378 by Kotaro Satoh co-workers, caffeic acid-derived styrene monomer amenable to RAFT polymerization, which one the emerging methodologies for polymer synthesis. Combined with protection/deprotection processes, polymerization results in welldefined functional block copolymers consist...

This research article focuses on the synthesis of ionic liquids from glucosamine, a renewable material obtained chitin. Our group previously experienced some obstacles in these glucosamine-based liquids, often due to sterical hindrance induced by dimethylated amino-group. In this work we present method using Borch reductive amination overcome limitations achieve dimethylethylamino-group. We fur...

Herein we present a highly efficient, light-mediated, deoxygenative protocol to access γ-oxo-α-amino acid derivatives. This radical methodology employs photoredox catalysis, in combination with triphenylphosphine, generate acyl radicals from readily available (hetero)aromatic and vinylic carboxylic acids. approach allows for the straightforward synthesis of acids bearing wide range functional g...

A single clean, good-yielding, environment-friendly microwave-assisted procedure for O-silylation of uridine with tert-butyldimethylsilyl chloride (TBDMSCl), 1,8-Diazabicyclo(5.4.0)undec-7-ene (DBU) and potassium nitrate as catalyst under solvent-free conditions is reported. Subsequent silyl ether deprotection accomplished a reusable acidic resin via microwave irradiation. Both the silylation d...

Effective methodologies for efficient preparation of semicarbazones from aldehydes or ketones via milling and the subsequent regeneration of the parent carbonyls by gaseous nitrogen dioxide are described under solid-solid and gas-solid reaction conditions, respectively. These methods are fast, simple and environmentally benign which do not require the use of any auxiliaries such as catalyst...