Background: When searching for reliable and specific markers for certain psychiatric diseases, preliminary investigations of the sleep EEG’s microstructure point to the view that the delta/beta correlation coefficients during NREM sleep appear increased in depressives, but not in schizophrenics. Therefore, this parameter could be hypothesized to be a marker of depression. On the other hand, sub...

Sixty percent of cases of clinical depression are considered to be treatment-resistant depression (TRD). Magnesium-deficiency causes N-methyl-d-aspartate (NMDA) coupled calcium channels to be biased towards opening, causing neuronal injury and neurological dysfunction, which may appear to humans as major depression. Oral administration of magnesium to animals led to anti-depressant-like effects...

Results from studies using a behavioral high-risk design and approximations to it generally have corroborated the cognitive vulnerability hypothesis of depression, whereas results from remitted depression studies typically have not. Suspecting that design features of previously conducted remitted designs likely precluded them from detecting maladaptive cognitive patterns, the authors conducted ...

Si la remission de depression est lobjectif therapeutique principal, frequence remissions partielles reste elevee. Les symptomes les plus frequemment rapportes sont propres a notamment lanxiete et lirritabilite, lhumeur depressive, lasthenie troubles du sommeil. etudes sur avec residuels restent peu nombreuses concernent surtout des populations patients hospitalises ou forme sevère depressio...

Eighty-nine depressed outpatients were studied by clinical criteria, Research Diagnostic Criteria (RDC), and the dexamethasone suppression test (DST) of neuroendocrine regulation. A simple outpatient version of the DST, requiring only one blood sample, correctly identified 40% of patients diagnosed clinically as endogenous depression (ED), with a specificity of 98% and a diagnostic confidence o...

There have been two important developments in the surgical treatment of mental disorders during the last 12 years, and one of these is in the selection of patients. No longer is the chronic schizophrenic the principal type of patient selected for cerebral surgery. The patients now considered for surgical treatment are usually chronic depressives and those with anxiety states, and obsessional sy...

BACKGROUND Previous reports have shown a significant relationship between suicide ideation and mixed depression. The aim of this study was to explore the prevalence and clinical characteristics of mixed depression among non-violent suicide attempters. METHODS Using a structured interview (modified Mini International Neuropsychiatric Interview) and assessing all the symptoms of 16 psychiatric ...

Way back in 1898 Freud, the propounder of psychoanalysis and enunciator of psychological concepts of mental illnesses wrote to his friend Fliess—"I have no desire at all to leave the psychology hanging in the air with no organic basis but beyond the feeling of conviction (that there must be such a basis), I have nothing either theoretical or therapeutic to work on and so I must behave as if con...

One of the most important functions of REM sleep and dreaming is mood-regulation. Clinical observations suggest the putative role of REM sleep in relation to the problem-solving functions of REM sleep (1). REM sleep and dream content are profoundly altered in affective disorders, thus an analysis of the relationship between mood, REM sleep, and dreaming may play a role in our understanding of u...

1699 EEG Activity Markers in Depression—Birchler-Pedross et al be quantified by spectral EEG correlates in the low-frequency range (1-7 Hz) during sleep and wakefulness.13-19 The intensity of low-frequency EEG activity at the beginning of sleep is proportional to the duration of prior wakefulness, and is considered to reflect the homeostatic aspect of sleep regulation.20-22 During sustained wak...