Major depressive disorder is one of the most burdensome and debilitating diseases in the United States. In this pilot study, we present a new annotation scheme representing depressive symptoms and psycho-social stressors associated with major depressive disorder and report annotator agreement when applying the scheme to Twitter data.

BACKGROUND In a previous prospective study of 300 consecutive new attenders at neurology outpatient clinics, depressive disorders were diagnosed in 119 patients (40%) and major depressive disorder in 77 (26%). OBJECTIVE To describe the eight month outcome of depression in this cohort. METHODS Patients were reinterviewed eight months after their baseline assessment. Mental state was examined...

OBJECTIVE This study compared the severity of and the change in depressive symptoms among men with alcohol dependence, affective disorder, or both disorders during 4 weeks of inpatient treatment. METHOD After their primary and secondary psychiatric disorders were defined with the use of criteria based on chronology of symptoms, 54 unmedicated men entering treatment for alcohol dependence or a...

An audit has been carried out of the patients who have been assessed using the CAARMS tool in order to assess patients who have been judged to have a prodromal psychotic syndrome. Instead of advocating PRS, Johannessen & McGorry (Johannessen 2010), have offered an alternative: a 'Pluripotent risk syndrome'. This less specific prodrome reflects the unpredictable nature of "Ultra-High Risk" state...

OBJECTIVE This review will focus on the role of cytokines in the central nervous system and its implications to depressive disorder. We will then discuss the main findings of cytokine measurements in patients with major depressive disorder. METHOD We searched Pubmed for studies published from 1999-2007, using the keywords depression and cytokine; and depressive disorder and cytokine. We have ...

The purpose of this study was to evaluate the associations between weight status and mental disorders, including depressive disorder, anxiety disorder and alcohol use disorder. A total of nationally representative 6,510 subjects aged 18-64 yr was interviewed in face-to-face household survey. Response rate was 81.7%. Mental disorders were diagnosed using the Korean version of the Composite Inter...

Depressive symptoms are highly prevalent and clinically relevant in schizophrenia spectrum disorder (SSD) patients. So far, little is known about to what extent the depressive symptom profile SSD comparable that seen major (MDD). Data were derived from Genetic Risk Outcome of Psychosis study (GROUP) Netherlands Study Depression Anxiety (NESDA). We examined differences severity profiles distribu...

Terminology Mood disorders are characterized by pervasive dysregulation of mood and psychomotor activity and by related biorhythmic and cognitive disturbances. The rubric of “affective disorder,” which in some European classifications also subsumes morbid anxiety states, is increasingly being replaced by the nosologically more delimited concept of “mood disorder.” Thus mood disorder is now the ...