a series of 42 pyrazolo[4,3-h]quinazoline-3-carboxamides as multi-cyclin-dependent kinaseinhibitors regarded as promising antitumor agents to complement the existing therapies, wassubjected to a three-dimensional quantitative activity relationship (3d qsar). different qsarmethods, comparative molecular field analysis (comfa), comfa region focusing, andcomparative molecular similarity indices an...

this paper deals with a delayed ratio-dependent functional response predator-prey model with a threshold harvesting policy. we study the equilibria of the system before and after the threshold. we show that the threshold harvesting can improve the undesirable behavior such as nonexistence of interior equilibria. the global analysis of the model as well as boundedness and permanence properties a...

introduction: although tolerance to and dependence on opioids are characterized by excessive activity of camp pathway in some brain stem nuclei, the impact of morphine dependence on activity of camp pathway in paragigantocellularis nucleus (pgi), located in the rostral ventrolateral medulla, remains unclear. therefore, the effect of adenyl cyclase activator forskolin on spontaneous firing rate ...

Laminar stagnation flow, axi-symmetrically yet obliquely impinging on a rotating circular cylinder, as well as its heat transfer is formulated as an exact solution of the Navier-Stokes equations. Rotational velocity of the cylinder is time-dependent while the surface transpiration is uniform and steady. The impinging stream is composed of a rotational axial flow superposed onto irrotational rad...

In this paper, the non-Fourier heat conduction in a semi-infinite body was examined. The heat wave non-Fourier heat conduction model was used for thermal analysis. Thermal conductivity was assumed temperature-dependent which resulted in a non-linear equation. The heat source was also considered temperature-dependent which resulted in a non-homogeneous equation. The Mac-Cormack predictor-correct...

The accelerating fields (e. g. centrifugal acceleration and constant acceleration) can change the physical performance of nano-sensors significantly. Herein, a new size-dependent model is developed to investigate the scale-dependent dynamic behavior of nanowire-fabricated sensor operated in an accelerating field. The scale-dependent equation of motion is developed by employing a consolidation o...

introduction: depression is one of the most common psychiatric problems. the prevalence of depression in iran has been estimated about 10-35% in females and 5-9% in males. nicotine is a narcotic substance and approximately 22% of american people are dependent on it. one of the notorious outcomes of nicotine-dependency is behavioral problems. the aim of this study was to find the relationship be...