In this study, we investigated the role of liver X receptor (LXR) activation in hepatic assembly and in the secretion of very low density lipoprotein-triglycerides in goose primary hepatocytes. Goose primary hepatocytes were isolated and treated with the LXR agonist T0901317. Total triglyceride accumulation, intracellular and extracellular triglyceride concentrations, extracellular very low den...

results saffron extracts markedly (p < 0.05) decreased the serum total cholesterol (tc, 90 ± 9.3), triglyceride (tg, 99 ± 10.5), and low-density lipoprotein cholesterol (ldl-c, 27 ± 1.1) in obese rats, while they increased the serum high-density lipoprotein cholesterol (hdl-c, 68 ± 2.2). the atherosclerosis-index (ldl/hdl, 0.39 ± 0.5), atherogenic index (tc/hdl, 1.32 ± 4.2), and the liver enzym...

OBJECTIVE The molecular mechanisms underlying sex differences in dyslipidemia are poorly understood. We aimed to distinguish genetic and hormonal regulators of sex differences in plasma lipid levels. APPROACH AND RESULTS We assessed the role of gonadal hormones and sex chromosome complement on lipid levels using the four core genotypes mouse model (XX females, XX males, XY females, and XY mal...

BACKGROUND Elevated serum levels of oxidized Low-density Lipoprotein (oxLDL) have been found in type 2 and in poorly controlled diabetic patients. Gestational diabetes mellitus (GDM) has common features with type 2 diabetes. OBJECTIVE The aim of our study was to evaluate the serum levels of oxLDL in women with GDM compared to normal pregnant women. MATERIALS AND METHODS In this cross-sectio...

CONTEXT Unfavorable lipid levels contribute to cardiovascular disease and may also harm bone health. OBJECTIVE Our objective was to investigate relationships between fasting plasma lipid levels and incident fracture in midlife women undergoing the menopausal transition. DESIGN AND SETTING This was a 13-year prospective, longitudinal study of multiethnic women in five US communities, with ne...

OBJECTIVES To investigate the prevalence of dyslipoproteinemia in a homogeneous cohort of polyarticular juvenile idiopathic arthritis patients. METHODS Based on the National Cholesterol Education Program, fasting lipoprotein levels and risk levels for coronary artery disease were determined in 28 patients with polyarticular juvenile idiopathic arthritis. The exclusion criteria included diabet...