Lipoproteins may supply substrate for the formation of bile acids, and the amount of hepatic cholesterol can regulate bile-acid synthesis and increase cholesterol 7alpha-hydroxylase expression. However, the effect of lipoprotein cholesterol on sterol 27-hydroxylase expression and the role of different lipoproteins in regulating both enzymes are not well established. We studied the effect of dif...

1. We have studied the plasma lipoprotein abnormalities in obstructive jaundice to test the hypothesis that the abnormalities would correlate with plasma lecithin--cholesterol acyltransferase activity. 2. Very-low-density lipoproteins (VLDL) were normal in composition and had a normal pre-beta electrophoretic mobility when lecithin--cholesterol acyltransferase activity was high. When it was low...

Cholesterol efflux from cultured cells can be mediated through binding of high density lipoprotein (HDL) to a cell-surface site which shows many characteristics of a biological receptor. To determine whether a specific protein forms a component of this site, cell membrane proteins were analyzed by ligand blotting using 125I-HDL3. Results demonstrated that membranes from a number of cell types p...

BACKGROUND AND OBJECTIVE As atherosclerosis is a lifelong process, prevention of exposure to its risk factors should start at an early age. Our aim was to study the influences of repeated low saturated fat dietary counseling on dietary intakes and lipoprotein measures from infancy to adulthood. METHODS Dietary intakes (food records) and serum lipid profile were studied annually from 7 months ...

background: studies demonstrated controversial results on subclinical hypothyroidism (sch) regarding lipid profile alteration with or without levothyroxine treatment. the purpose of this study is to investigate the effects of levothyroxine on serum lipids in sch. materials and methods: one hundred patients with sch referred to taleghani hospital in kermanshah were recruited and randomly assigne...

objective(s):resveratrol (res) is a polyphenol compound that has been shown a promising cardioprotective effect. however, some reports have yielded conflicting findings. herein, we investigated the anti-atherosclerotic effects of res in apolipoprotein e (apo e)-deficient mice on a high cholesterol diet. materials and methods: firstly, atherosclerosis was induced by feeding a high cholesterol di...

To investigate the role of various lipoproteins in plasma to promote cholesterol efflux from cell membranes, potencies of lipoproteins in normolipidemic fasting and postprandial (PP) plasmas to accept additional cholesterol molecules from cell membranes were determined. We used red blood cells (RBCs) and lipoproteins in fresh blood as donors and acceptors of cell membrane cholesterol, respectiv...

Abbreviations: LDL-C: Low-density-lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol; BPH: Benign prostatic hypertrophy; PARP: ADP ribose polymerase; H2O2: Hydrogen peroxide; X: Xanthine; XO: Xanthine oxidase; BDNF: Brain-derived neurotrophic factor; pCREB: Phosphorylated cAMP response element binding-protein; pERK: Phosphorylated extracellular signal-regulated kinase; NO: Nit...

AIM To explore the relationship between retinal vessel atherosclerosis and serum concentrations of total cholesterol, triglycerides, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, HDL(2) cholesterol, HDL(3) cholesterol, apoprotein B, apoprotein A-I, and apoprotein A-II. METHODS Lipids and lipoproteins were measured in 101 male patients aged between 26 a...