The molecular mechanisms that regulate growth cone guidance of dendrite outgrowth remain to be elucidated. We hypothesized that mRNA localization in dendritic growth cones and their local protein synthesis may be important for growth cone functioning. The appearance of 23 of 31 growth cone mRNAs was developmentally regulated. Also, alteration of growth cone morphology affected the relative leve...

This paper presents a synopsis of some recent work, still in progress, aimed at elucidating a quantitative explanation of the processes by which flow chimneys form when certain types of alloys are directionally solidified. If (for example) light fluid is released at the liquid-solid "mushy" (dendrite) zone, and cooling is from below, then the intermediate fluid flow undergoes convection through...

Mutations in the leucine-rich repeat kinase 2 (LRRK2) have been associated with familial and sporadic cases of Parkinson disease. Mutant LRRK2 causes in vitro and in vivo neurite shortening, mediated in part by autophagy, and a parkinsonian phenotype in transgenic mice; however, the underlying mechanisms remain unclear. Because mitochondrial content/function is essential for dendritic morphogen...

Lithium Metal Batteries In article number 2202206, Jianan Wang, Wei Yan, and co-workers discuss the intractable uncontrollable safety issues, like thermal runaway dendrite growth (represented by erupting volcano rugged terrain) in operation of lithium metal batteries (LMBs). The presented thermally stable dendrite-resistant separators road) provide a safe choice for LMBs to operate under extrem...

Much is known about the functions and properties of neuronal dendrites, but rarely has dendritic activation been monitored while the dendrite performs a computational task. In this issue of Neuron, Bollmann and Engert demonstrate that different regions of a dendrite in the tadpole optic tectum are tuned to stimuli in different locations of the visual field. Their study is the first direct demon...

The immature processes that give rise to both axons and dendrites contain microtubules (MTs) that are uniformly oriented with their plus-ends distal to the cell body, and this pattern is preserved in the developing axon. In contrast, developing dendrites gradually acquire nonuniform MT polarity orientation due to the addition of a subpopulation of oppositely oriented MTs (Baas, P. W., M. M. Bla...