نتایج جستجو برای: deletion of object marker ra
تعداد نتایج: 21194163 فیلتر نتایج به سال:
OBJECTIVE Metalloproteinases (MMP) play an important role in the remodelling of the extracellular matrix. However, evidence that they are responsible for tissue damage in pathological situations remains circumstantial. Stromelysin (MMP-3) production is increased in rheumatoid arthritis (RA), and has been proposed as a marker of joint damage. The relevance of serum levels of MMP-3 to erosions in...
Upon breaching of the endometrial surface epithelium, the implanting embryo embeds in the decidualizing stroma. Retinoic acid (RA), a metabolite of vitamin A, is an important morphogen during embryonic and fetal development, although the role of the RA pathway in the surrounding decidual cells is not understood. Here we show that decidual transformation of human endometrial stromal cells (HESCs...
IL-1 is an inflammatory cytokine that has been widely implicated in Rheumatoid Arthritis (RA). In Saudi Arabia, limited work has addressed the genetic bases of RA. In this case-control study, association of single nucleotide polymorphisms (SNPs) in the IL-1 gene is investigated in a well characterized Saudi cohort. Keeping in view the genetic heterogeneity of Saudi population, blood samples fro...
The current trend in genome-wide association studies is to identify regions where the true disease-causing genes may lie by evaluating thousands of single-nucleotide polymorphisms (SNPs) across the whole genome. However, many challenges exist in detecting disease-causing genes among the thousands of SNPs. Examples include multicollinearity and multiple testing issues, especially when a large nu...
In rheumatoid arthritis (RA), synovial inflammation results in focal erosion of articular bone. Despite treatment attenuating inflammation, repair of erosions with adequate formation of new bone is uncommon in RA, suggesting that bone formation may be compromised at these sites. Dynamic bone histomorphometry was used in a murine model of RA to determine the impact of inflammation on osteoblast ...
Background and Objectives: Non-Alcoholic Steatohepatitis (NASH) is a serious and increasing liver dis-ease, which develops into cirrhosis, fibrosis, and hepatocellular carcinoma. Rosmarinic Acid (RA) is a powerful antioxidant and anti-inflammatory compound. Therefore, this study aimed to assess the role of RA on a mouse model of NASH-induced liver fibrosis. Methods: In this research, C57/BL6 mi...
The aim of this study was to assess circulating levels of reactive oxygen metabolites (ROMs) as a marker of oxidative stress in rheumatoid arthritis (RA) patients during an anti-tumor necrosis factor alpha (TNF-α) treatment. We enrolled 40 patients with RA (36 females; age 53 ± 13 yrs) treated with different subcutaneously administered TNF-α inhibitors. The oxidative status was determined on th...
BACKGROUND A defect in hypothalamic-pituitary-adrenal (HPA) axis function has been suggested to contribute to susceptibility to rheumatoid arthritis (RA). OBJECTIVE To investigate polymorphisms of the glucocorticoid receptor (GR) gene and determine any associations with RA. METHODS Three GR polymorphisms that tag 95% of all haplotypes across the GR gene were genotyped. These are an intron B...
Augmented Reality (AR) applications are one of the current mobile app trends. Its ability to display information as if make user merge with provided. The specialty application is in marker. One marker that great demand known markerless, such 3D Object Tracking. In making this Object-based AR application, must pass a stage where real object taken at points or be used markers. markers vuforia sca...
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