نتایج جستجو برای: dehydro aromatization

تعداد نتایج: 1931  

Journal: :Cancer research 2003
Tina L Tinley Rachel M Leal Deborah A Randall-Hlubek James W Cessac Lynne R Wilkens Pemmaraju N Rao Susan L Mooberry

2-Methoxyestradiol (2-ME2) is a natural estrogen metabolite that, while devoid of estrogenic effects, has both antiangiogenic and antitumor effects. 2-ME2 is currently being evaluated in Phase I and Phase II clinical trials for the treatment of multiple types of cancer. Novel analogues of 2-ME2 were tested for activities that predict antiangiogenic and antitumor effects. Selected analogues were...

Journal: :Chest 2003
Shintaro Tanaka Hiroshi Tanaka Shosaku Abe

BACKGROUND The circadian variation in urinary leukotriene E(4) (LTE(4)) excretion with a morning acrophase has recently been reported in nocturnal asthma (NA); however, the effects of inhaled corticosteroids (ICS) on this circadian rhythmicity of leukotriene (LT) in patients with NA are controversial. METHODS We first measured peak expiratory flow (PEF), urinary LTE(4), 11-dehydro-thromboxane...

Journal: :Chemical communications 2012
Penchal Reddy Nandaluru Prateek Dongare Christina M Kraml Robert A Pascal Louise N Dawe David W Thompson Graham J Bodwell

A very short synthesis (5 steps), the crystal structure and resolution of an elaborate, inherently chiral [n](1,6)pyrenophane is reported. The synthesis hinges upon two very productive events: a multicomponent reaction and an unprecedented double-McMurry/valence isomerization/dehydrogenation step. Aromatization reactions are involved in the formation of all four of the rings of the pyrene system.

Journal: :Organic & biomolecular chemistry 2012
Nataliya A Markina Anton V Dubrovskiy Richard C Larock

The reaction of readily accessible 1,1-dialkylhydrazones with commercially available o-(trimethylsilyl)aryl triflates provides a direct one-step route to pharmaceutically important 1-alkylindazoles. The products are obtained in high yields by one-pot NCS-chlorination/aryne annulation or Ac(2)O-acylation/deprotection/aromatization protocols.

Journal: :Organic & biomolecular chemistry 2015
Hirokazu Kage Elena Riva James S Parascandolo Martin F Kreutzer Manuela Tosin Markus Nett

Synthetic chain terminators were used to capture the biosynthetic intermediates from a partially reducing iterative type I polyketide synthase, which is integrated into a multimodular biosynthesis enzyme. The off-loaded metabolites clarified the timing of ketoreduction and aromatization in the assembly of the antibiotic micacocidin.

2014
Gadi Ranjith Kumar Yalla Kiran Kumar Ruchir Kant Maddi Sridhar Reddy

The copper-catalyzed ketenimine formation reaction of 1-(o-acetamidophenyl)propargyl alcohols with various sulfonyl azides is found to undergo a concomitant intramolecular nucleophile attack to generate 1,2-dihydro-2-iminoquinolines after aromatization (via elimination of acetyl and hydroxy groups) and tautomerization. The reaction produces 4-substituted and 3,4-unsubstituted title compounds in...

Journal: :Proceedings of the National Academy of Sciences 2011

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