A c-Met inhibitor tivantinib is a candidate anticancer agent for patients with hepatocellular carcinoma (HCC), and CYP2C19 is the key metabolic enzyme for tivantinib. Previous Japanese phase I studies in patients with solid tumors (except HCC) recommend 360 mg twice daily (BID) and 240 mg BID for CYP2C19 extensive metabolizers (EM) and poor metabolizers (PM), respectively. In this study, Japane...

Growth factors have been shown to protect cells from a variety of apoptotic stimuli. In the liver, the Fas system is thought to be very important in the genesis of hepatocyte apoptosis. Others have already shown the importance of the phosphatidylinositol 3-kinase (PI3-kinase) pathway and of increased Bcl-xl expression in the antiapoptotic effect of growth factors on hepatocytes. We investigated...

Bid opening in sealed-bid e-auction is efficient when a homomorphic encryption algorithm is employed to seal the bids and homomorphic bid opening is employed to open the bids. Such e-auction schemes are called homomorphic auctions. However, high efficiency of homomorphic auctions is based on an assumption: the bids are valid (e.g. within a special range). An undetected invalid bid can compromis...

Discrepancies between current body image perception and desired body image represent levels of body image dissatisfaction (BID). This study investigated the relationship between BID and multidimensional self-concept in adolescents from the Western Australian Pregnancy Cohort (Raine) Study. We hypothesized that BID is influenced by specific domains of the self-concept with gender differences. Th...

Bid, a proapoptotic member of Bcl-2 family, is involved in Fas receptor signaling. Fas activation promotes human eosinophil cell death and is believed to accelerate the resolution of pulmonary Th2-driven allergic reaction in mice. We hypothesized that Bid would regulate eosinophil apoptosis and Ag-induced airway inflammation, particularly eosinophilia. C57BL/6 Bid(-/-) and wild-type mice were i...

In this work we introduce the class of graphs with bounded induced distance of order k, (BID(k) for short). A graph G belongs to BID(k) if the distance between any two nodes in every connected induced subgraph of G is at most k times their distance in G. These graphs can model communication networks in which node failures may occur: at a given time, if sender and receiver are still connected, a...

We consider the problem faced by a seller in determining an optimal price to quote in response to a Request for Quote (RFQ) from a prospective buyer. The optimal price is determined by maximizing expected profit, given the underlying seller costs of the bid items and a computed probability of winning the bid as a function of price and other bid features such as buyer characteristics and the deg...