Gene delivery is a powerful technique that often exploited in the treatment of several diseases.

Reversible modifications of reversible addition–fragmentation chain transfer (RAFT)-polymerization derived end groups are usually limited to reductive degradable disulfide conjugates. However, self-immolative linkers can promote ligation and traceless release primary secondary amines as well alcohols via carbonates or carbamates in ?-position disulfides. In this study, these two strategies comb...

Large degradable dendrimers (MW > 30 kDA) were synthesized in a divergent manner utilizing a novel 1,3,5-triazaadamantane (TAA) monomer that can degrade under acidic conditions.

Ruminant feed evaluation systems use constant minimum requirements of rumen-degradable protein (RDP) and often relate this to apparently degradable organic matter (OM). However, studies with tropical forages indicate that RDP: apparently degraded OM might not be constant across high-fiber diets. This was tested with semi-continuous ruminal cultures (Rusitec) using dried contrasting low-protein ...

degradable poly(benzyl malate) derivatives; cyclic RGD peptide; HepaRG hepatoma cells. 14 15 ABSTRACT 16 Amphiphilic derivatives of poly(benzyl malate) were synthesized and characterized with the aim of 17 being used as degradable and biocompatible building blocks for the design of functional nanoparticles 18 (NPs). An anti-cancer model drug, doxorubicin, has been successfully encapsulated into...

The ability to genetically modify mesenchymal stem cells (MSCs) seeded inside synthetic hydrogel scaffolds would offer an alternative approach to guide MSC differentiation. In this report, we explored gene transfer to MSCs seeded on top or inside matrix metalloproteinase (MMP) degradable hydrogels that were loaded with DNA/poly(ethylene imine) (PEI) polyplexes. DNA/PEI polyplexes were encapsula...