نتایج جستجو برای: defensins
تعداد نتایج: 1854 فیلتر نتایج به سال:
Human neutrophil defensins, and their analogues incorporating anionic, hydrophobic or cationic residues at the N- and C-termini, were synthesized by solid-phase procedures. The synthetic defensins were examined for their microbicidal activity against Candida albicans, two Gram-negative bacteria (Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis) and two Gram-positive bacteria (S...
WE WRITE TO RETRACT AN INTERPRETATION IN our Report, “Contribution of human αdefensin 1, 2, and 3 to the anti–HIV-1 activity of CD8 antiviral factor” (1), wherein we demonstrated that human α-defensin 1, 2, and 3 account for much of the anti–HIV-1 activity of the CD8 antiviral factor (CAF) that is not attributable to β-chemokines. Although the antiviral activity of human αdefensin has not been ...
α-Defensins are an important class of abundant innate immune effectors that are potently antiviral against a number of nonenveloped viral pathogens; however, a common mechanism to explain their ability to block infection by these unrelated viruses is lacking. We previously found that human defensin 5 (HD5) blocks a critical host-mediated proteolytic processing step required for human papillomav...
Antimicrobial peptides (AMPs), of which big defensins are examples, are an important component of the natural defenses of most living organisms, and possess remarkable microbicidal activities. In the present study, using expressed-sequence tag sequences from a cDNA library and RACE, the full-length cDNA sequence of the big defensin gene from the triangle-shell pearl mussel, Hyriopsis cumingii, ...
BACKGROUND Interstitial lung disease (ILD) is the leading cause of mortality in patients with systemic sclerosis (SSc). Although the pathogenesis of SSc-ILD is not well understood, neutrophils may play a pivotal role in this process. Neutrophils store azurophil granules that contain defensins, antimicrobial peptides that function in regulating the inflammatory response, and IL-8, a potent chemo...
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