The purpose of this study is to develop and characterize the nature of a solid dispersion system of nifedipine in a polymer matrix consisting of PVP K30 and poloxamer 407. Dispersions consist of drug, polymeric carrier and surfactant carrier. Binary solid dispersions consisting of nifedipine and PVP K30 were developed by solvent evaporation method. Poloxamer 407, surfactant carrier was incorpor...

We developed solid dispersions, using the gas anti-solvent technique (GAS), to improve the oral bioavailability of the poorly water-soluble active component oridonin. The solubility of oridonin in supercritical carbon dioxide was measured under various pressures and temperatures. To prepare oridonin solid dispersions using the GAS technique, ethanol was used as the solvent, CO(2) was used as th...

The filtration behaviour of some clay–water dispersions was studied. Two Spanish fibrous phyllosilicates (sepiolite from Vicálvaro and palygorskite from Turón) and a commercial bentonite (Bentopharm©, UK) with similar sizes and different morphologies (fibrous and/or laminar) were selected as model clays. Sepiolite from Vicálvaro is an almost pure fibrous sample, Bentopharm© presents a high amou...

in this work attempts were made to evaluate k+-sds and hydrocolloid polymer-sds interactions in flocculation of megestrol acetate dispersions to enhancetheir stability as a part of suspension formulation. different dispersions of micronized megestrol acetate and sds were prepared. kcl and kh2po4 and their corresponding sodium salts were added to the dispersions and the preparations were evaluat...

meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. the aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (peg) 6000. the effect of solubilization by...