OBJECTIVE To determine changes in physical and social function during a prolonged preoperative waiting period and at 3 months after total knee arthroplasty. SUBJECTS Forty-three patients were evaluated on the day that surgery was decided, the day before surgery, and 3 months afterwards. METHODS Knee pain and function were assessed using a visual analogue scale and a functional assessment sy...

Abstract Background The COVID-19 pandemic has prompted a lockdown in many countries to control the exponential spread of SARS-CoV-2 virus, hereby reducing time-varying basic reproduction number ( R t ) below one. Governments are looking for evidence balance demand their citizens ease some restriction, against fear new peak infections. In this study, we wanted quantify relative contribution mobi...

'^ I. SUMMARY Decreased contractility has been reported in the diabetic heart. Because a close correlation exists between contractility and the activity of Ca ATPase of purified actinomyosin and myosin, Ca ATPase activity was determined in control and diabetic rats. In control rats, actinomyosin ATPase was 0.59 ± 0.05 /xmol Pi/mg protein/min and had decreased by 35% to 0.38 ± 0.04 in diabetic r...

Huntington's disease (HD) is caused by expanded glutamine repeats within the huntingtin (Htt) protein. Mutant Htt (mHtt) in the cytoplasm has been linked to induction of the luminal endoplasmic reticulum (ER) stress pathway, the unfolded protein response (UPR). How mHtt impacts the susceptibility of the ER lumen to stress remains poorly understood. To investigate molecular differences in the ER...

Burns to the upper extremity and axilla frequently result in the formation of contractures that can impede shoulder range of motion. The purpose of this study was to determine the long-term effects of upper extremity burn scar contracture release on motion during activities of daily living in the first year postrelease. Upper extremity motion analysis was conducted on children aged 4 to 17 year...

OBJECTIVE To investigate the relationship between white matter abnormalities and impairment of gait and balance in older persons. METHODS Quantitative MRI was used to evaluate the brain tissue compartments of 28 older individuals separated into normal and impaired groups on the basis of mobility performance testing using the Short Physical Performance Battery. In addition, individuals were te...

Nonenzymatic glycation of low density lipoprotein (LDL) is a reaction of glucose and other reducing sugars with apolipoprotein B100 (apo-B100) lysine residues. In diabetes, this reaction is greatly accelerated and is important in the pathogenesis of diabetic complications. The objective of this study was to investigate in vitro effects of ?-tocopherol, ascorbic acid and lycopene on LDL glycatio...