نتایج جستجو برای: de novo
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In this paper, 4 microRNAs and their targets were predicted through a de novo prediction procedure in the genome of Porcine Reproductive and Respiratory Syndrome virus. Through clustalW analysis, these 4 microRNAs were recognized as novel PRRSV derivate microRNAs. Target prediction results showed PRRSV mir-1, 2 and 4 have total 16 targets in porcine 3’ UTR database. These targets could be divid...
Advent of Next Generation Sequencing has led to possibilities of de novo transcriptome assembly of organisms without availability of complete genome sequence. Among various sequencing platforms available, Illumina is the most widely used platform based on data quality, quantity and cost. Various de novo transcriptome assemblers are also available today for construction of de novo transcriptome....
SECOND to chronic allograft dysfunction, membranous nephropathy (MN) is the most frequent cause of nephrotic syndrome in renal transplantation. This pathology can be caused by recurrence of the primary renal disease, the development of de novo glomerulopathy, or by a transplanted glomerular disease (present but unrecognized in the donor). De novo MN was first described more than 25 years ago 3 ...
Metagenomic studies have primarily relied on de novo approaches for reconstructing genes and genomes from microbial mixtures. While database driven approaches have been employed in certain analyses, they have not been used in the assembly of metagenomic data. This is in part due to the small size and biased coverage of public genome databases, but also due to the inherent computational cost of ...
Infectious proteins (prions) can arise de novo as well as by transmission from another individual. De novo prion generation is believed responsible for most cases of Creutzfeldt-Jakob disease and for initiating the mad cow disease epidemic. However, the cellular components needed for prion generation have not been identified in any system. The [URE3] prion of Saccharomyces cerevisiae is an infe...
The de novo origin of a new protein-coding gene from non-coding DNA is considered to be a very rare occurrence in genomes. Here we identify 60 new protein-coding genes that originated de novo on the human lineage since divergence from the chimpanzee. The functionality of these genes is supported by both transcriptional and proteomic evidence. RNA-seq data indicate that these genes have their hi...
Comment citer ce document : Benoit, G. (Auteur de correspondance), Peterlongo, P., Mariadassou, M., Drezen, E., Schbath, S., Lavenier, D., Lemaitre, C. (2017). Simka: large scale de novo comparative metagenomics. In: JOBIM 2017 LILLE (p. 3-5). Presented at JOBIM 2017 Journées Ouvertes Biologie Informatique Mathématiques, Lille, FRA (2017-07-03 2017-07-06). Simka: large scale de novo comparative...
Post-transplant malignancy is the major cause of later death of recipients after liver transplantation. Tumor recurrence after liver transplantation for patients with hepatocellular carcinoma in the end stage of cirrhosis has been frequently encountered. However, de novo hepatocellular carcinoma originating from the liver allograft has only rarely been reported. Here we reported a case of de no...
Translocations at chromosomal band 11q23 characterize most de novo acute lymphoblastic leukemias (ALL) of infants, acute myeloid leukemias (AML) of infants and young children, and secondary AMLs following epipodophyllotoxin exposure. The chromosomal breakpoints at 11q23 have been cloned from isolated cases of de novo ALL and AML. Using an 859-base pair BamHI fragment of human ALL-1 complementar...
We have undertaken a genome-wide analysis of rare copy-number variation (CNV) in 1124 autism spectrum disorder (ASD) families, each comprised of a single proband, unaffected parents, and, in most kindreds, an unaffected sibling. We find significant association of ASD with de novo duplications of 7q11.23, where the reciprocal deletion causes Williams-Beuren syndrome, characterized by a highly so...
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