Oncofetal fucose-rich glycovariants of the pathological bile salt-dependent lipase (pBSDL) appear during human pancreatic oncogenesis and are detected by themonoclonal antibody J28 (mAbJ28). We aimed to identify murine counterparts onpancreatic ductal adenocarcinoma (PDAC) cells and tissue and investigate the potential of dendritic cells (DC) loaded with this unique pancreatic tumor antigen to ...

Dendritic cells (DCs) have been shown to play a key role in the initiation and maintenance of immune responses to microbial pathogens as well as to allergens, but the exact mechanisms of their involvement in allergic responses and Th2 cell differentiation have remained elusive. Using retagging, we identified DC-SIGN as a novel receptor involved in the initial recognition and uptake of the major...

Mycobacterium tuberculosis is a highly successful human pathogen that primarily resides in host phagocytes, such as macrophages and dendritic cells (DCs), and interferes with their functions. Although multiple strategies used by M. tuberculosis to modulate macrophage responses have been discovered, interactions between M. tuberculosis and DCs are less well understood. DCs are the primary APCs o...

Costimulatory cross-talk can occur at multiple cellular levels to potentiate expansion and polarization of Th responses. Although OX40L ligand (OX40L) is thought to play a key role in Th2 development, the critical cellular source of this molecule has yet to be identified. In this study, we demonstrate that OX40L expression by the initiating dendritic cell (DC) is a fundamental requirement for o...

A simple method for the generation of a chirp-free optical pulse train with tunable pulse width using a polarization modulator (PolM) and a zero-chirp intensity modulator (IM) is proposed and demonstrated. In the proposed system, a light wave with its polarization direction oriented at an angle of 45 degrees with respect to the principal axis of the PolM is polarization modulated by a sinusoida...

The quantum nonlocal correlation of states plays an important role in the information and computing protocols. However, during transmission entangled channel, they will inevitably interact with environment, resulting degradation coherence then weakening correlation. Using a high probability testing scheme based on Hardy-type paradox, this paper we investigate two-qubit polarization when transmi...

Polymorphonuclear neutrophils (PMN) play a central role in inflammation and participate in its control, notably by modulating dendritic cell (DC) functions via soluble mediators or cell-cell contacts. Neutrophil extracellular traps (NETs) released by PMN could play a role in this context. To evaluate NET effects on DC maturation, we developed a model based on monocyte-derived DC (moDC) and cali...

Typical Specifications (Dual Channel) Parameters / Model # SRF-24120910-D1 SRF-35121010-D1 SRF-77121210-D1 RF frequency 24.150 GHz 35.500 GHz 76.500 GHz Transmitter output power +10 dBm (typical) +10 dBm (typical) +10 dBm (typical) Receiver conversion loss 9 dB (typical) 10 dB (typical) 12 dB (typical) IF bandwidth DC to 100 MHz (minimum) DC to 100 MHz (minimum) DC to 100 MHz (minimum) I/Q Chan...

Leptin is an adipose-secreted hormone that plays an important role in both metabolism and immunity. Leptin has been shown to induce Th1-cell polarization and inhibit Th2-cell responses. Additionally, leptin induces Th17-cell responses, inhibits regulatory T (Treg) cells and modulates autoimmune diseases. Here, we investigated whether leptin mediates its activity on T cells by influencing dendri...

Effective accumulation and interaction of mature dendritic cells (DCs) and naïve T cells within lymph nodes (LNs), driven by the CCR7-CCL19/CCL21 axis, are critical for the induction of adaptive T cell immunity. Human natural killer (NK) cells activated by IL-18 exhibit unique ‘helper’ activity in promoting productive DC-T cell interactions, inducing dendritic cell (DC) maturation and the type-...