نتایج جستجو برای: dapk gene
تعداد نتایج: 1141463 فیلتر نتایج به سال:
Effect of shear stress and substrate on endothelial DAPK expression, caspase activity, and apoptosis
Promoter hypermethylation plays an important role in the inactivation of cancer-related genes. This abnormality occurs early in leukemogenesis and seems to be associated with poor prognosis in acute lymphoblastic leukemia (ALL). To determine the extent of hypermethylation in ALL, we analyzed the methylation status of the CDH1, p73, p16, p15, p57, NES-1, DKK-3, CDH13, p14, TMS-1, APAF-1, DAPK, P...
PURPOSE Our goal was to define tumor and saliva gene methylation profile of head and neck squamous cell carcinoma and to evaluate its prognostic significance and its biomarker potential for early detection of relapse. EXPERIMENTAL DESIGN We prospectively analyzed 11 genes by methylation-specific PCR on primary tumors, histologically normal adjacent mucosa, and saliva from 90 French patients a...
BACKGROUND AND AIM Genetic alterations in the normal tissues surrounding various cancers have been described, but a comprehensive analysis of this carcinogenic field effect in Barrett's-associated adenocarcinoma of the esophagus disease has not been reported. The aim of this study was to analyze the gene expression profile of a panel of highly selected genes in the normal squamous esophagus epi...
PURPOSE To identify epigenetic molecular makers in plasma for the early detection of colorectal cancer. EXPERIMENTAL DESIGN We retrospectively analyzed the methylation status of 10 genes in fresh-frozen tissues and corresponding plasma samples from 243 patients with stage I and II sporadic colorectal cancer, 276 healthy individuals, and plasma from 64 colorectal adenoma patients using methyla...
Feng et al. ( 1 ) examined whether changes in DNA methylation of 20 genes, selected on the basis of their role in cervical cancer, could be used as markers of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC). The authors found varying frequencies of promoter hypermethylation in these 20 genes in 319 exfoliated cell samples and matched tissue biopsy specimens. For four...
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