Natural composites achieve damage tolerance through a complex microstructure with several hierarchical levels; this has inspired the development of synthetic microstructures, in order to overcome their inherent brittleness. However, while most natural have non-self-similar designs literature use self-similar features. The aim work is therefore investigate whether could be more tolerant than equ...

The field of DNA damage responsiveness in general, and the consequences of endogenous and exogenous base damage in DNA, in particular, has made new and exciting contributions to our increasing understanding of the initiation and progression of neoplasia in humans. This article presents some of the highlights in this area of investigation, with a particular emphasis on DNA repair, the tolerance ...