نتایج جستجو برای: dab
تعداد نتایج: 1389 فیلتر نتایج به سال:
OBJECTIVE To investigate the cellular and molecular sources of oxidative stress in patients with rheumatoid arthritis (RA) through analysis of the production of reactive oxygen species (ROS) in synovium. METHODS Cytochemical procedures based on the 3,3'-diaminobenzidine (DAB)-Mn2+ deposition technique were used on unfixed cryostat sections of synovium from RA patients and rheumatic disease co...
The efficacy of protein-based medicines can be compromised by their rapid clearance from the blood circulatory system. Achieving optimal pharmacokinetics is a key requirement for the successful development of safe protein-based medicines. Protein PEGylation is a clinically proven strategy to increase the circulation half-life of protein-based medicines. One limitation of PEGylation is that ther...
In the rat and other species “labile― methyl groups are essential to normal metabolism (5). These are methyl groups which are capable of be ing transferred in toto from one compound to an other by specific enzymes and enzyme cofactors. In the rat the major source of such groups is the diet, which may contain them in the form of such compounds as i@-methionine, choline, betaine, and possibly...
Greenstein in 1942 found a high content of alka line phosphatase in transplanted rat hepatoma 31 (3). This tumor arose originally in the liver of a male Osborne-Mendel rat and was induced by the basal diet of White and Jackson (16) containing 0.06 percent />-diinethylaniinoazobenzene (DAB) with intermittent addition of 0.5 per cent cystine and 0.5 per cent methionine (17). The enzyme ac tivity ...
For the dual active bridge (DAB) DC-DC converters, parameter uncertainty (circuit parameters, input and/or load perturbations) affect their performance, such as dynamic performance and backflow power. Here, to deal with uncertainties, a robust model predictive control (RMPC) for DAB converter under extended-phase-shift (EPS) is proposed improve reduce power of first time. First, cost function c...
Flexibility and choice -The DAB signal is essentially a highly flexible over-air 'data-pipe' that can broadcast a wide range of service types, from purely audio-based to multimedia. Typically, each multiplex can broadcast five or more high-quality audio services plus a number of extra services. The multiplex can be dynamically reconfigured to introduce additional services, temporary or permanen...
Tumour Necrosis Factor-α (TNF-α) inhibition has been transformational in the treatment of patients with inflammatory disease, e.g. rheumatoid arthritis. Intriguingly, TNF-α signals through two receptors, TNFR1 and TNFR2, which have been associated with detrimental inflammatory and beneficial immune-regulatory processes, respectively. To investigate if selective TNFR1 inhibition might provide be...
BACKGROUND Venous malformation (VM) consists of a network of ectatic anomalous thin-walled venous channels. A role for an activating TIE2 mutation in the development of the dilated luminal vessels in VM, and its proposed involvement of embryonic stem cells (ESCs), led us to investigate the expression of ESC markers in subcutaneous VM (SCVM) and intramuscular VM (IMVM). METHODS Formalin-fixed ...
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