Dopamine (DA) D1-like receptors are present in pathways implicated in feedback control of midbrain DA neurons. However, stimulation of these receptors either produces no effect on DA cells, or the effect is inconsistent. It is possible that the expression of a D1 feedback effect requires co-activation of D2-like receptors. To test this hypothesis, we recorded extracellularly the spontaneous act...

Cristina Anton, Arthur Vicentini da Costa Luiz, Filomena Marino Carvalho, Edmund Chada Baracat, Jesus Paula Carvalho I Obstetrics and Gynecology – Faculdade de Medicina da Universidade de São Paulo São Paulo/SP, Brazil. II Pathology – Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brazil. III Gynecology – Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São P...

This paper presents a model of both tonic and phasic dopamine (DA) effects on maintenance of working memory representations in the prefrontal cortex (PFC). The central hypothesis is that DA modulates the efficacy of inputs to prefrontal pyramidal neurons to prevent interferences for active maintenance. Phasic DA release, due to DA neurons discharges, acts at a short time-scale (a few seconds), ...

................................................................................................................8 1 INTRODUÇÃO .........................................................................................................9 1.1 Interações, objetividade-entre-parênteses e o estudo do domínio cognitivo dos empreendedores das PME..............................................................

Trabalho realizado na Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo USP Ribeirão Preto (SP) Brasil. 1 Doutora, Professora da Faculdade de Ciências Médicas da Pontifícia Universidade Católica de Campinas PUC Campinas (SP) Brasil. 2 Doutor, Professor do Departamento de Clínica Médica da Faculdade de Ciências Médicas da Universidade Estadual de Campinas UNICAMP Campinas (SP)...

Somatodendritic dopamine (DA) released in substantia nigra pars compacta (SNc) and the ventral tegmental area (VTA) may mediate extrasynaptic neuronal signaling. The concentration of extracellular DA ([DA]o) attained during somatodendritic activation will be governed by the density of release sites and properties of DA uptake. We evaluated these factors in SNc, VTA, and dorsal striatum with car...

Dysfunctional dopamine (DA)-mediated signaling is implicated in several diseases including Parkinson’s disease, schizophrenia and attention deficit and hyperactivity disorder. Chronic treatment with DA receptor agonists or antagonists is often used in pharmacotherapy, but the consequences of these treatments on DA neuron function are unclear. It was recently demonstrated that chronic D2 autorec...

BACKGROUND AND PURPOSE Three-dimensional digital subtraction angiography (DSA) is useful as a supplement to 2D DSA in the pretreatment evaluation of intracranial aneurysms. However, the clinical efficacy of 3D digital angiography (DA) that is generated from unsubtracted rotational images has not been established. The purpose of this study was to assess whether 3D DA provides additional useful i...

Ductus arteriosus (DA) closure follows constriction and remodeling of the entire vessel wall. Patent ductus arteriosus occurs when the DA does not close after birth, and this condition is currently treated using cyclooxygenase inhibitors. However, the efficacy of cyclooxygenase inhibitors is often limited. Our previous study demonstrated that low-dose thromboxane A2 receptor (TP) stimulation co...

We examined the ventilatory effects of exogenous dopamine (DA) and norepinephrine (NE) administration in chloralose-anesthetized, paralyzed, artificially ventilated adult goats before and after carotid body denervation (CBD). Intravenous (iv) DA bolus injections and slow iv infusions caused dose-dependent inhibition of phrenic nerve activity (PNA) in carotid body (CB)-intact animals during norm...