Some 2-thiouracils and fused 2-thiouracils were evaluated for their cytotoxicity study .The synthesized compounds were tested for their cytotoxicity effects towards (CaCo-2) cancer cell line using SRB assay. The results showed that compound 1b displayed promising cytotoxic activity and found to be more potent than standard, doxorubicin.

Recent years have seen an increase in the acceptance of green chemistry as a viable method for producing nanoparticles. The aim this work was to investigate cytotoxicity, antioxidant effect, and hemocompatibility zinc oxide nanoparticles (ZnO NPs) produced utilizing Capparis spinosa L. (C. L.) fruit extract powerful reducing agent. reaction rate ZnO NPs’ shape concerning concentration, contact ...

Abstract Today bone tissue engineering is one of the most used technologies for treat bones injure. Materials containing hydroxyapatite and graphene have received much attention recently. The aim this study was preparation biogenic bioceramics modified by graphene-like structures investigation effect on structure properties material. Biogenic were successfully prepared chemical vapor deposition...

In this work, we developed a microfluidic device for the imitation of drug metabolism in human liver and its cytotoxicity on cells. The integrated microfluidic device consists of three sections: (1) bioreactors containing poly(ethylene) glycol (PEG) hydrogel encapsulated human liver microsomes (HLMs); (2) cell culture chambers for cytotoxicity assay; and (3) integrated micro solid-phase extract...

Background/Aim. Amalgam has been used for years in dentistry, but the controversy on its adverse effects, both local oral/dental tissues and systemic health, still exists. When retrograde filling apical surgery, amalgam comes close contact with periapical tissue, it is sometimes responsible induction of lesion (PL) or exacerbation. Therefore, aim study was to examine effect cytotoxicity product...

Background: Vernonia amygdalina is generally known as sour leaf or bitter which one among the medically significant plants in African and Mediterranean regions. Hence, this study aids biosynthesis of copper nanoparticles using V.amygdalina for first time further it aims to investigate cytotoxicity, antioxidant anti-inflammatory properties mediated nanoparticles. Methods: Cytotoxic effect Copper...

Background and objectives:Scrophularia variegata M. Beib. (Scrophulariaceae) is a medicinal plant, used for various inflammatory diseases in Iranian Traditional Medicine. In the present study, we evaluated the immune modulation and antioxidant effects of the hydroalcoholic extract of S.  variegata. Methods: The splenocytes were harvested...

Lichens are resilient organisms, known for their unique profiles of secondary metabolites and for exhibiting antioxidative, antibacterial, and cytotoxic effects. Analyzing the cytotoxic potential of Lobaria scrobiculata, a bioassay-guided fractionation strategy yielded seven known metabolites, with two of these compounds, 2 and 3, exhibiting cytotoxicity against HL-60 cells. In order to verify ...

The bicyclo compounds possess a wide variety of activities so, in the present study we have develop a novel and simple method for the synthesis of such 3, 4-diphenyl-2, 5-diaza-bicyclo [4.3.1] decane derivatives. All the compounds synthesized were characterized by running TLC, IR, NMR and LCMS spectra. All the title compounds were screened for the determination of Cytotoxicity by MTT and SRB as...

Microcystin-LR and -LA were readily biodegraded by a bacterium, Sphingpoyxis sp. LH21, in a treated reservoir water. Detection of the microcystins was conducted using high-performance liquid chromatography (HPLC), protein phosphatase 2A (PP2A) inhibition assay and a cell-based cytotoxicity assay. The HPLC results correlated well with the two assays. The decrease in cytotoxicity, coupled with th...